{"id":"W2972417083","doi":"10.1212/wnl.0000000000008377","title":"<i>APOE</i> ε4, white matter hyperintensities, and cognition in Alzheimer and Lewy body dementia","year":2019,"lang":"en","type":"article","venue":"Neurology","topic":"Neurological Disease Mechanisms and Treatments","field":"Neuroscience","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Heart and Stroke Foundation; Sunnybrook Health Science Centre","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; IXICO; H. Lundbeck A/S; Eisai; University of Toronto; Servier; Pfizer; Biogen; BioClinica; Sunnybrook Research Institute; Northern California Institute for Research and Education; Fondation Brain Canada; F. Hoffmann-La Roche; Alzheimer Society; Alzheimer's Society; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Ionis Pharmaceuticals; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Hyperintensity; Lewy body; Dementia; White matter; Dementia with Lewy bodies; Medicine; Cognition; Neuroscience; Alzheimer's disease; Psychology; Lewy body disease; Pathology; Magnetic resonance imaging; Disease; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003625848,0.0001436214,0.0001752614,0.0000660259,0.00004617477,0.00002910523,0.00006115332,0.00007645063,0.0004158492],"category_scores_gemma":[0.00001443508,0.0001241699,0.00002138397,0.00005927905,0.00009097303,0.0001023996,0.0001209754,0.0001517164,0.0002701659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001489518,"about_ca_system_score_gemma":0.000005098466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001681321,"about_ca_topic_score_gemma":0.000008707431,"domain_scores_codex":[0.9988452,0.0001392635,0.0001357234,0.0005238993,0.00008684986,0.0002690397],"domain_scores_gemma":[0.9996495,0.00008678647,0.00003966442,0.0001372538,0.000009487621,0.00007734656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001165219,0.0003600755,0.6783909,0.00002495678,0.00004342681,0.001060878,0.00007842272,0.000007554706,0.3148009,0.002517036,0.0003517829,0.001198763],"study_design_scores_gemma":[0.003015436,0.0021074,0.9709721,0.000006503816,0.0001732333,0.0005349304,0.00000577425,0.000610619,0.01398679,0.005388872,0.002890539,0.0003078548],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951727,0.0001352173,0.000004226973,0.001406349,0.0002036463,0.0002752013,0.00001797852,0.00003118739,0.002753477],"genre_scores_gemma":[0.9701357,0.00007679665,0.00001232586,0.02967161,0.0000123277,0.00002235275,0.000003881905,0.00001487816,0.00005011255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3008142,"threshold_uncertainty_score":0.50635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02037283306171341,"score_gpt":0.229625032215132,"score_spread":0.2092521991534186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}