{"id":"W2972417083","doi":"10.1212/wnl.0000000000008377","title":"<i>APOE</i> ε4, white matter hyperintensities, and cognition in Alzheimer and Lewy body dementia","year":2019,"lang":"en","type":"article","venue":"Neurology","topic":"Neurological Disease Mechanisms and Treatments","field":"Neuroscience","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Heart and Stroke Foundation; Sunnybrook Health Science Centre","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; IXICO; H. Lundbeck A/S; Eisai; University of Toronto; Servier; Pfizer; Biogen; BioClinica; Sunnybrook Research Institute; Northern California Institute for Research and Education; Fondation Brain Canada; F. Hoffmann-La Roche; Alzheimer Society; Alzheimer's Society; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Ionis Pharmaceuticals; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Hyperintensity; Lewy body; Dementia; White matter; Dementia with Lewy bodies; Medicine; Cognition; Neuroscience; Alzheimer's disease; Psychology; Lewy body disease; Pathology; Magnetic resonance imaging; Disease; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005047516,0.0006722029,0.0006723602,0.001534877,0.0004962407,0.0009960661,0.0007783129,0.0008855572,0.001441935],"category_scores_gemma":[0.006361767,0.0004202708,0.00354185,0.001341957,0.0005877247,0.0004300489,0.0006088432,0.0006111113,0.000102057],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004812844,"about_ca_system_score_gemma":0.0006337092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01541804,"about_ca_topic_score_gemma":0.01611088,"domain_scores_codex":[0.9984612,0.0008697971,0.0001648245,0.0002401927,0.000167272,0.00009668164],"domain_scores_gemma":[0.9953725,0.00242557,0.001435056,0.000347993,0.0001983805,0.0002205438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003312457,0.0001141989,0.9658909,0.0005357349,0.02044255,0.0001970511,0.0000921633,0.0003454007,0.0004658808,0.0001189735,0.0003091275,0.008175622],"study_design_scores_gemma":[0.0001931149,0.0003359181,0.9840541,0.0001706108,0.01280181,0.0002135649,0.0001058654,0.0008967692,0.0003204934,0.000406311,0.0004848947,0.00001647344],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9632069,0.0340534,0.0005701412,0.0004851858,0.00008452729,0.00003456289,0.0005202023,0.00002017032,0.001024853],"genre_scores_gemma":[0.997066,0.00176457,0.0004265425,0.0001443163,0.00006575606,0.00002258871,0.0002439574,0.000003835262,0.0002625551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01541804,"threshold_uncertainty_score":0.03065658,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02037283306171341,"score_gpt":0.229625032215132,"score_spread":0.2092521991534186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}