{"id":"W2972463318","doi":"10.3390/nu11092207","title":"Protein Intake at Twice the RDA in Older Men Increases Circulatory Concentrations of the Microbiome Metabolite Trimethylamine-N-Oxide (TMAO)","year":2019,"lang":"en","type":"article","venue":"Nutrients","topic":"Diet and metabolism studies","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institutes of Health; European Commission; National Institute of Diabetes and Digestive and Kidney Diseases; Ministry of Business, Innovation and Employment; AgResearch","keywords":"Trimethylamine N-oxide; Metabolite; Metabolome; Internal medicine; Endocrinology; Biomarker; Microbiome; Medicine; Insulin resistance; Carnitine; Trimethylamine; Insulin; Physiology; Chemistry; Biology; Biochemistry; Bioinformatics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002582924,0.0003273898,0.0004816403,0.0001331808,0.000191967,0.0002564987,0.000108178,0.0003258888,0.0009819171],"category_scores_gemma":[0.0003820363,0.000219719,0.0003248391,0.0001504184,0.0001618568,0.0001348952,0.0002188566,0.0003563547,0.0001610106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001209922,"about_ca_system_score_gemma":0.0001515048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001642028,"about_ca_topic_score_gemma":0.002324159,"domain_scores_codex":[0.9998965,0.00003287684,0.000008275186,0.00002461984,0.00001588806,0.00002184148],"domain_scores_gemma":[0.9998307,0.00002433772,0.00005192695,0.00001810258,0.00001481311,0.0000600424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.150511,0.007521205,0.3313226,0.0009308037,0.001501157,0.0005533395,0.000865967,0.0002491681,0.4331446,0.0000684768,0.0009599144,0.07237175],"study_design_scores_gemma":[0.0005353324,0.02546765,0.9674727,0.00002404812,0.0003593281,0.000156162,0.0001900679,0.0002246075,0.004847368,0.00003918333,0.0006722889,0.00001120826],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993556,0.0004398991,0.00004725972,0.00002049972,0.00001138054,0.000005958583,0.000042296,0.000004723302,0.00007228175],"genre_scores_gemma":[0.9984231,0.0003896445,0.0002050924,0.00008791326,0.0000159787,0.00002271841,0.000111311,0.000002225896,0.0007420473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001642028,"threshold_uncertainty_score":0.003284872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01048496094180145,"score_gpt":0.2440817114326045,"score_spread":0.2335967504908031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}