{"id":"W2972463857","doi":"10.1038/s41587-019-0241-9","title":"Hidden antibiotics in actinomycetes can be identified by inactivation of gene clusters for common antibiotics","year":2019,"lang":"en","type":"article","venue":"Nature Biotechnology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":94,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Antibiotics; Actinobacteria; Biology; Microbiology; Phylum; Gene; Bacteria; Antimicrobial; Genetics; Computational biology; 16S ribosomal RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.000204592,0.0001827119,0.0005000135,0.0003599745,0.00003022577,0.000009001798,0.0002046917,0.001661146,0.00001539154],"category_scores_gemma":[0.0003578888,0.0001523244,0.00007895711,0.0004591534,0.0001212197,0.00005132475,0.00006375409,0.0008044522,0.000002372627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001166418,"about_ca_system_score_gemma":0.00005135298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008950794,"about_ca_topic_score_gemma":0.00007332337,"domain_scores_codex":[0.9988122,0.00002462638,0.0003435893,0.0003994882,0.0001354015,0.0002846719],"domain_scores_gemma":[0.9990698,0.0001074369,0.000227942,0.0004423981,0.0001190415,0.00003338308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002848477,0.0001281969,0.004886663,0.0002512815,0.00005179337,0.000003068128,0.00003219224,4.230064e-7,0.9855309,0.0004840428,0.002724695,0.005621865],"study_design_scores_gemma":[0.00131145,0.0003307378,0.002786222,0.0001058411,0.00005268967,0.00002430488,0.0001421562,0.00007090646,0.9897426,0.0000642001,0.005213057,0.0001558581],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9758713,0.0005241551,0.00001695988,0.0219252,0.000431777,0.0009684087,0.000122108,0.00006516714,0.0000749618],"genre_scores_gemma":[0.99564,0.0001475751,0.002954688,0.0006727194,0.00006272691,7.933903e-8,0.0001903901,0.00002546736,0.0003063586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02125248,"threshold_uncertainty_score":0.9996349,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008883546536880327,"score_gpt":0.2571027561043425,"score_spread":0.2482192095674622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}