{"id":"W2972473004","doi":"10.1182/blood.v128.22.4245.4245","title":"Results from Ongoing Phase 2 Trial of SL-401 in Patients with Advanced, High-Risk Myeloproliferative Neoplasms Including Chronic Myelomonocytic Leukemia","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Interleukin-3 receptor; Chronic myelomonocytic leukemia; Myelofibrosis; Internal medicine; Myeloid; Myeloid leukemia; Oncology; Plasmacytoid dendritic cell; Immunology; Myeloproliferative neoplasm; Leukemia; Hematology; Bone marrow; Cancer research; Myelodysplastic syndromes; Immune system; Dendritic cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002463078,0.001327725,0.001162682,0.0002733159,0.0004242086,0.0007839488,0.0005818518,0.001398577,0.004394566],"category_scores_gemma":[0.0007639356,0.0002494807,0.0009625468,0.0002350556,0.0005097266,0.0008089052,0.0003427478,0.002210502,0.0008855015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006562102,"about_ca_system_score_gemma":0.001359603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006269182,"about_ca_topic_score_gemma":0.001460996,"domain_scores_codex":[0.9995205,0.0002149928,0.00002950918,0.00006359958,0.00005651638,0.0001148358],"domain_scores_gemma":[0.9992809,0.000132558,0.0001127208,0.00005814745,0.00006938655,0.000346452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5888349,0.08297849,0.01383821,0.001214806,0.001787869,0.0006305836,0.0004255518,0.004106122,0.0663017,0.0006217736,0.01279144,0.2264686],"study_design_scores_gemma":[0.4676941,0.4944161,0.02033059,0.00008441784,0.0005482766,0.000552306,0.00007214246,0.001245544,0.005649772,0.0005897774,0.008780395,0.00003658862],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9806623,0.003146993,0.001182589,0.001249821,0.0001854599,0.005252614,0.003075975,0.0001752952,0.005069008],"genre_scores_gemma":[0.9611896,0.002473903,0.004826389,0.002749929,0.0002998446,0.00908966,0.0125291,0.00005069631,0.006790825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004394566,"threshold_uncertainty_score":0.01470125,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008983238579847404,"score_gpt":0.2300691876969023,"score_spread":0.2210859491170549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}