{"id":"W2972488366","doi":"10.21037/tlcr.2019.09.08","title":"Current perspectives on statins as potential anti-cancer therapeutics: clinical outcomes and underlying molecular mechanisms","year":2019,"lang":"en","type":"review","venue":"Translational Lung Cancer Research","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":111,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Geranylgeranyl pyrophosphate; Statin; Mevalonate pathway; Farnesyl pyrophosphate; Cancer; HMG-CoA reductase; Apoptosis; Cancer research; Bioinformatics; Pharmacology; Limiting; Cancer prevention; Cancer cell; Reductase; Enzyme; Internal medicine; Biology; Biochemistry; Biosynthesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008872376,0.0004520814,0.00102372,0.0002424415,0.0002000809,0.00009962403,0.0003850485,0.0004168976,0.0001665045],"category_scores_gemma":[0.00003335796,0.0003786777,0.0006240044,0.0002020111,0.000260951,0.00001070746,0.00009385664,0.000988476,0.00001783177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009679746,"about_ca_system_score_gemma":0.002049301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001258452,"about_ca_topic_score_gemma":0.00004559084,"domain_scores_codex":[0.9961202,0.0006609678,0.0005938851,0.001110387,0.0009521906,0.0005624019],"domain_scores_gemma":[0.9987079,0.0001647625,0.0001731437,0.0004548746,0.0003283235,0.0001709823],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002007015,0.0002990806,0.000211148,0.004459117,0.002142172,8.28876e-7,0.0002382221,0.0001209842,0.001123529,0.009887472,0.001094803,0.9802219],"study_design_scores_gemma":[0.0009995294,0.0001844356,0.0003376254,0.001333368,0.000629245,0.000003741099,0.00009308882,0.00004431617,0.00004246223,0.0002862985,0.9955522,0.0004936265],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007688862,0.9916735,0.001720245,0.0002699857,0.003356328,0.001411808,0.0006101775,0.0000148852,0.0001742116],"genre_scores_gemma":[0.001162287,0.9940796,0.0001307045,0.0001000708,0.00321952,0.0003706667,0.000292969,0.0001038757,0.0005402723],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9944575,"threshold_uncertainty_score":0.9998665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1949678051607571,"score_gpt":0.5406074981371674,"score_spread":0.3456396929764103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}