{"id":"W2972514808","doi":"10.1016/j.nbd.2019.104613","title":"One-carbon metabolism supplementation improves outcome after stroke in aged male MTHFR-deficient mice","year":2019,"lang":"en","type":"article","venue":"Neurobiology of Disease","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"Natural Sciences and Engineering Research Council of Canada; Council of Ontario Universities","keywords":"Methylenetetrahydrofolate reductase; Homocysteine; Internal medicine; Stroke (engine); Endocrinology; Medicine; Lesion; Vitamin B12; Physiology; Surgery; Biology; Biochemistry; Allele","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003542644,0.001023406,0.001399133,0.001061069,0.0003574138,0.0005319288,0.0006840341,0.001116737,0.002074395],"category_scores_gemma":[0.000227243,0.0004303534,0.0007908488,0.0003392572,0.0003716392,0.0004974818,0.0003217784,0.001379509,0.001041199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004114527,"about_ca_system_score_gemma":0.0004467836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001743624,"about_ca_topic_score_gemma":0.002499704,"domain_scores_codex":[0.9996569,0.00003205135,0.00006196428,0.00009037142,0.00005976947,0.00009893058],"domain_scores_gemma":[0.999535,0.00001428056,0.0001610897,0.00004631135,0.00005314537,0.0001902537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004354332,0.001134749,0.0006788562,0.0001325062,0.00006826704,0.0002240412,0.00006579818,0.0001137993,0.9873062,0.00007178921,0.0003607498,0.005488933],"study_design_scores_gemma":[0.001470782,0.03303449,0.03838303,0.0002003147,0.0006589334,0.001369733,0.0003009691,0.002255575,0.9131037,0.0005781926,0.00855529,0.00008892624],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932026,0.001930404,0.001280356,0.0003857149,0.0001402946,0.00006232016,0.001734234,0.0003961939,0.0008679201],"genre_scores_gemma":[0.9767265,0.003861483,0.003049985,0.0004290125,0.00008057151,0.0002801536,0.003699788,0.0001601439,0.01171243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002074395,"threshold_uncertainty_score":0.00693953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01843524999498164,"score_gpt":0.2970706007047603,"score_spread":0.2786353507097787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}