{"id":"W2972518525","doi":"10.1016/j.ijrobp.2019.06.594","title":"The Genomic Landscape of Anal Cancer and Its Relationship to Clinical Outcomes: An Exploratory Analysis of NRG Oncology/RTOG 98-11","year":2019,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Colorectal and Anal Carcinomas","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Juravinski Cancer Centre","funders":"","keywords":"Medicine; Oncology; PTEN; Cancer; Internal medicine; Cisplatin; Cancer research; Radiation therapy; PI3K/AKT/mTOR pathway; Chemotherapy; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001356912,0.0001533136,0.0008637991,0.0003525937,0.00005601465,0.00001047028,0.0003232987,0.0002263731,0.00008178401],"category_scores_gemma":[0.0005222578,0.0001077433,0.0003937966,0.0004035696,0.0001391711,0.0001728648,0.00008547818,0.0003977213,0.00001045058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002829807,"about_ca_system_score_gemma":0.0007549065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003097466,"about_ca_topic_score_gemma":0.0002276679,"domain_scores_codex":[0.9977939,0.0003521776,0.00119264,0.0002250128,0.0002703134,0.0001660266],"domain_scores_gemma":[0.9958321,0.001441536,0.001356579,0.0001704805,0.001018735,0.0001805044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008120284,0.0002890665,0.9800262,0.000007875702,0.001676082,0.000007506529,0.000579303,0.0007680134,0.001524063,0.003691227,0.0001670547,0.0104516],"study_design_scores_gemma":[0.002633951,0.001991353,0.987118,0.00002071411,0.0009835658,0.00001621903,0.0003494295,0.003188913,0.0001859803,0.0007428694,0.002668099,0.0001008784],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948505,0.0006471598,0.0001757597,0.002613465,0.001194238,0.0002057824,0.00007406649,0.000008812485,0.000230246],"genre_scores_gemma":[0.9975869,0.0005856818,0.0002597471,0.0006661151,0.000756742,0.000008464795,0.00004173916,0.00001378024,0.00008082287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01035072,"threshold_uncertainty_score":0.4393643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05556480097997721,"score_gpt":0.3921811788950093,"score_spread":0.3366163779150321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}