{"id":"W2972521239","doi":"10.1016/j.celrep.2019.08.029","title":"Tracing Tumor Evolution in Sarcoma Reveals Clonal Origin of Advanced Metastasis","year":2019,"lang":"en","type":"article","venue":"Cell Reports","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Cancer Institute; National Institutes of Health","keywords":"Biology; Metastasis; clone (Java method); Sarcoma; Cancer research; Primary tumor; Somatic evolution in cancer; Cancer; Gene; Pathology; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002076485,0.00009131618,0.0001671949,0.00004505743,0.00001214594,0.000005358918,0.00005371164,0.00005104603,0.00002916502],"category_scores_gemma":[0.00007361087,0.00009611179,0.00009061658,0.00007771652,0.00001942264,0.000002986358,0.00004491935,0.00005134711,0.0000037742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003840728,"about_ca_system_score_gemma":0.0001251604,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005864311,"about_ca_topic_score_gemma":0.00003825954,"domain_scores_codex":[0.999121,0.00001794713,0.0003394603,0.0002704326,0.00009490325,0.000156295],"domain_scores_gemma":[0.999354,0.00001608647,0.0002159011,0.0003181163,0.00005386216,0.00004200014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004662485,0.0000656102,0.0653765,0.00005406215,0.00001088055,0.00005820679,0.00001748397,0.001536347,0.9317151,0.00004740181,0.0002748417,0.0007969427],"study_design_scores_gemma":[0.0006351302,0.0002439778,0.04706631,0.0000507218,0.00002612302,0.000115685,0.00008598542,0.0000383039,0.9353088,0.000596617,0.01559006,0.0002423551],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945367,0.00193647,0.000182884,0.00001157821,0.0002711734,0.0001885132,0.00001143484,0.000003114705,0.002858106],"genre_scores_gemma":[0.998343,0.00006707753,0.0009884946,0.00004380685,0.00005336514,0.000009444251,0.00004749771,0.00001332174,0.0004340083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01831019,"threshold_uncertainty_score":0.3919325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006928287100693281,"score_gpt":0.2401528260151975,"score_spread":0.2332245389145042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}