{"id":"W2972521239","doi":"10.1016/j.celrep.2019.08.029","title":"Tracing Tumor Evolution in Sarcoma Reveals Clonal Origin of Advanced Metastasis","year":2019,"lang":"en","type":"article","venue":"Cell Reports","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Cancer Institute; National Institutes of Health","keywords":"Biology; Metastasis; clone (Java method); Sarcoma; Cancer research; Primary tumor; Somatic evolution in cancer; Cancer; Gene; Pathology; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001209541,0.0001207274,0.0001320048,0.0003939378,0.0001178307,0.0002687292,0.00009972365,0.0001678018,0.0005085978],"category_scores_gemma":[0.0001569762,0.0001265264,0.0001105435,0.000152282,0.0001314052,0.000152344,0.0002276442,0.0003491947,0.0001583003],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002486942,"about_ca_system_score_gemma":0.0001255468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009184771,"about_ca_topic_score_gemma":0.001890599,"domain_scores_codex":[0.9999129,0.00000883895,0.000003718738,0.00002725817,0.00003077286,0.00001660129],"domain_scores_gemma":[0.9998205,0.00004241491,0.00005575101,0.00001911185,0.00003093027,0.00003117022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00003413218,0.000007622211,0.003259908,0.0000124351,0.000003209467,0.00004350079,0.00003181287,0.0002323125,0.9930897,0.000168771,0.0000336048,0.003082983],"study_design_scores_gemma":[0.000006217796,0.0002046087,0.06629981,0.00000999562,0.00002273952,0.0006682552,0.00007905019,0.01201771,0.9171646,0.0003722907,0.003141234,0.00001348155],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875008,0.000600416,0.010448,0.00002997791,0.00000430906,0.00001677428,0.0002855534,0.0001529092,0.0009612819],"genre_scores_gemma":[0.9936394,0.0003163047,0.004600004,0.00002146047,0.000002510346,0.00001508097,0.0002395407,0.00002503617,0.001140722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009184771,"threshold_uncertainty_score":0.001826227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006928287100693281,"score_gpt":0.2401528260151975,"score_spread":0.2332245389145042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}