{"id":"W2972536583","doi":"10.1101/768630","title":"Plasmid transmitted small multidrug resistant (SMR) efflux pumps differ in gene regulation and enhance tolerance to quaternary ammonium compounds (QAC) when grown as biofilms","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Integron; Plasmid; Efflux; Multiple drug resistance; Gene; Biology; Escherichia coli; Biofilm; Microbiology; Genetics; Promoter; Drug resistance; Bacteria; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001362233,0.000228218,0.0001997455,0.0002354257,0.00008683063,0.0002254939,0.0001075162,0.0001384602,0.0005506678],"category_scores_gemma":[0.0002131264,0.0001078873,0.0002032938,0.0001738811,0.0001165324,0.0001720084,0.0002330205,0.0003108751,0.0001672368],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001429348,"about_ca_system_score_gemma":0.000107781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005373204,"about_ca_topic_score_gemma":0.0006872886,"domain_scores_codex":[0.9998742,0.00001985657,0.00001312032,0.00002491928,0.0000378623,0.00002995111],"domain_scores_gemma":[0.9998323,0.00004137264,0.00004894832,0.00001597714,0.00003362087,0.00002777598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002333102,0.00001259177,0.0004797981,0.00000737034,0.000002049248,0.00001106191,0.00001145761,0.00001019439,0.9991059,0.00001018015,0.000006092178,0.0003199426],"study_design_scores_gemma":[0.00001132663,0.0005386415,0.07465202,0.000008480527,0.000027072,0.0003580516,0.0001754499,0.001351049,0.9218252,0.00005662617,0.0009860637,0.0000100354],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991079,0.0001160944,0.0003860172,0.00001688785,0.000003076151,0.000007237484,0.0001420072,0.00001093144,0.0002098023],"genre_scores_gemma":[0.9965144,0.000138465,0.001628559,0.00002209758,0.000003007278,0.00001499535,0.000599895,0.000009453572,0.001069259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005506678,"threshold_uncertainty_score":0.001842141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008254688557641391,"score_gpt":0.2133386500710442,"score_spread":0.2050839615134029,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}