{"id":"W2972537114","doi":"10.18433/jpps30626","title":"PPAR γ agonist, pioglitazone, suppresses melanoma cancer in mice by inhibiting TLR4 signaling","year":2019,"lang":"en","type":"article","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Pioglitazone; TLR4; Agonist; Rosiglitazone; Receptor; Peroxisome proliferator-activated receptor; Chemistry; Tumor necrosis factor alpha; Cancer research; Endocrinology; Internal medicine; Melanoma; NF-κB; Inflammation; Pharmacology; Medicine; Diabetes mellitus","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001045259,0.0005843745,0.0003749307,0.0005651154,0.0001760245,0.0002070079,0.0002447095,0.0003851145,0.001634894],"category_scores_gemma":[0.00009680667,0.000185974,0.0002732138,0.0002631558,0.0002083989,0.0001888146,0.000131694,0.001318277,0.0004458071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002110872,"about_ca_system_score_gemma":0.0003367542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005015745,"about_ca_topic_score_gemma":0.001119853,"domain_scores_codex":[0.9999075,0.0000110409,0.000008213001,0.00001681673,0.00002740778,0.00002898007],"domain_scores_gemma":[0.9999163,0.000006002208,0.00003254075,0.000008265002,0.000008327157,0.00002857206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001562257,0.0009376088,0.0005100424,0.000158986,0.00001958674,0.00007438836,0.00001813351,0.0001374687,0.9892741,0.00008444786,0.0003109875,0.006912011],"study_design_scores_gemma":[0.0005742621,0.007634399,0.00898273,0.00006719975,0.0001330752,0.0003908154,0.00009324282,0.001615608,0.9713213,0.0002186609,0.008954731,0.00001403333],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864667,0.005250221,0.002611833,0.0005868386,0.0002295621,0.0001364884,0.001001823,0.0004848506,0.003231753],"genre_scores_gemma":[0.9814948,0.005130971,0.003254532,0.0003100877,0.0000637405,0.0002649065,0.001097657,0.00005032301,0.008332939],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001634894,"threshold_uncertainty_score":0.005469263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02538393568228692,"score_gpt":0.3537459790081175,"score_spread":0.3283620433258306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}