{"id":"W2972551820","doi":"10.1002/mnfr.201900662","title":"Coenzyme Q10 Upregulates Platelet cAMP/PKA Pathway and Attenuates Integrin αIIbβ3 Signaling and Thrombus Growth","year":2019,"lang":"en","type":"article","venue":"Molecular Nutrition & Food Research","topic":"Coenzyme Q10 studies and effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; University of Toronto; St. Michael's Hospital","funders":"Canadian Institutes of Health Research; Science, Technology and Innovation Commission of Shenzhen Municipality; Guangzhou Science, Technology and Innovation Commission; Guangdong Science and Technology Department; Canada Foundation for Innovation; National Natural Science Foundation of China; Heart and Stroke Foundation of Canada","keywords":"Platelet; Integrin; Dense granule; Platelet Glycoprotein GPIIb-IIIa Complex; Signal transduction; Pharmacology; Platelet activation; Chemistry; cAMP-dependent pathway; Coenzyme Q10; Medicine; Endocrinology; Internal medicine; Cell biology; Receptor; Biochemistry; Biology; G protein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001260085,0.0003949243,0.0003517036,0.0001884692,0.0001385064,0.0002291627,0.0002101815,0.0003489677,0.001697022],"category_scores_gemma":[0.0001397508,0.0001155432,0.0002869534,0.0001131942,0.0002631926,0.0001692498,0.0001803713,0.000655602,0.0002885374],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002825247,"about_ca_system_score_gemma":0.0002937986,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001790384,"about_ca_topic_score_gemma":0.001826973,"domain_scores_codex":[0.9998931,0.00002221106,0.000008215326,0.00001983134,0.00001917048,0.00003747103],"domain_scores_gemma":[0.9999282,0.000009500207,0.00002109302,0.000006656775,0.00001150196,0.00002310023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00436501,0.0005856535,0.0004717322,0.0002383612,0.00003763216,0.0001192831,0.00001984767,0.00008082367,0.9858241,0.00008333413,0.0003429048,0.00783134],"study_design_scores_gemma":[0.001525333,0.01430426,0.02392123,0.00005460608,0.0002236813,0.0005760507,0.0001329729,0.001836148,0.948126,0.0002127953,0.009062187,0.00002474532],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886961,0.007218245,0.001797008,0.0003837398,0.0001332065,0.00008715746,0.0002772457,0.0001015698,0.001305834],"genre_scores_gemma":[0.9926535,0.003145053,0.001042704,0.0002146113,0.00004012744,0.00008060015,0.00034429,0.00001403241,0.002465092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001790384,"threshold_uncertainty_score":0.005677164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01739253475747791,"score_gpt":0.2764037713339261,"score_spread":0.2590112365764482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}