{"id":"W2972551820","doi":"10.1002/mnfr.201900662","title":"Coenzyme Q10 Upregulates Platelet cAMP/PKA Pathway and Attenuates Integrin αIIbβ3 Signaling and Thrombus Growth","year":2019,"lang":"en","type":"article","venue":"Molecular Nutrition & Food Research","topic":"Coenzyme Q10 studies and effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; University of Toronto; St. Michael's Hospital","funders":"Canadian Institutes of Health Research; Science, Technology and Innovation Commission of Shenzhen Municipality; Guangzhou Science, Technology and Innovation Commission; Guangdong Science and Technology Department; Canada Foundation for Innovation; National Natural Science Foundation of China; Heart and Stroke Foundation of Canada","keywords":"Platelet; Integrin; Dense granule; Platelet Glycoprotein GPIIb-IIIa Complex; Signal transduction; Pharmacology; Platelet activation; Chemistry; cAMP-dependent pathway; Coenzyme Q10; Medicine; Endocrinology; Internal medicine; Cell biology; Receptor; Biochemistry; Biology; G protein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006090507,0.0002480811,0.0002799366,0.0001446449,0.0002487747,0.0001276915,0.0001787044,0.0002287642,0.00002592518],"category_scores_gemma":[0.0001404095,0.0002323676,0.00008487149,0.0002363425,0.0002496321,0.00001162164,0.0004614424,0.0003480403,0.00002473366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002660564,"about_ca_system_score_gemma":0.00004246603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006581116,"about_ca_topic_score_gemma":0.00003497025,"domain_scores_codex":[0.9978819,0.0002311919,0.000221171,0.0006875569,0.0003887021,0.0005894146],"domain_scores_gemma":[0.999023,0.00009238195,0.00004737921,0.0003348455,0.0003303965,0.0001719805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001928695,0.0001176981,0.0007643254,0.0002852941,0.0001273433,0.00002993366,0.0001125416,0.000005029661,0.9909953,0.0006723393,0.0061899,0.0005073529],"study_design_scores_gemma":[0.001825248,0.002473378,0.0006560299,0.000180054,0.00001159123,0.00006730694,0.0004761459,0.0001008356,0.9813052,0.001028773,0.01154979,0.0003256747],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843974,0.01352611,0.0001642401,0.000849226,0.00007248314,0.0007600425,0.00003877502,0.00002298745,0.0001687952],"genre_scores_gemma":[0.9974815,0.001583916,0.0002971319,0.0001293307,0.0001487766,0.00007729847,0.0001297481,0.00004572419,0.0001066332],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0130841,"threshold_uncertainty_score":0.9475677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01739253475747791,"score_gpt":0.2764037713339261,"score_spread":0.2590112365764482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}