{"id":"W2972559932","doi":"10.1158/1078-0432.ccr-17-3572","title":"A Phase I and Pharmacokinetic Study of Oral Dabrafenib in Children and Adolescent Patients with Recurrent or Refractory <i>BRAF</i> V600 Mutation–Positive Solid Tumors","year":2019,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Institutes of Health; Brain Tumour Charity; National Cancer Institute; KWF Kankerbestrijding; National Institute for Health and Care Research","keywords":"Refractory (planetary science); Pharmacokinetics; Medicine; Dabrafenib; Solid tumor; Mutation; Oncology; Internal medicine; Cancer; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005198866,0.0005552483,0.0007688671,0.000149725,0.0002291062,0.0003853888,0.0002479292,0.0003231295,0.001338755],"category_scores_gemma":[0.0005488968,0.0002989136,0.000476916,0.0002179038,0.0003788101,0.0002969882,0.0001408848,0.001542816,0.0003340581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000677051,"about_ca_system_score_gemma":0.001202827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001694069,"about_ca_topic_score_gemma":0.004026027,"domain_scores_codex":[0.9997848,0.0001051159,0.00001157561,0.00002997841,0.00003548797,0.00003310588],"domain_scores_gemma":[0.9996251,0.00005634302,0.00009827747,0.00002167307,0.00003519154,0.0001633552],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2225259,0.06247271,0.3000876,0.001072442,0.0023814,0.002786758,0.00184641,0.005113409,0.168615,0.0006968483,0.006960581,0.2254411],"study_design_scores_gemma":[0.1685905,0.4391935,0.3430136,0.00009309746,0.0008710796,0.005936696,0.000617203,0.003782969,0.02122421,0.0002243231,0.01639146,0.00006131452],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980646,0.0005866101,0.0002218065,0.00009372496,0.00001082855,0.0002858345,0.0002544705,0.00001031891,0.0004718222],"genre_scores_gemma":[0.996303,0.0009222681,0.0009835125,0.0001883816,0.00002357178,0.0003163189,0.0007705471,0.000008091016,0.0004843315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001694069,"threshold_uncertainty_score":0.004912376,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05948289162910631,"score_gpt":0.4552782093316713,"score_spread":0.395795317702565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}