{"id":"W2972559932","doi":"10.1158/1078-0432.ccr-17-3572","title":"A Phase I and Pharmacokinetic Study of Oral Dabrafenib in Children and Adolescent Patients with Recurrent or Refractory <i>BRAF</i> V600 Mutation–Positive Solid Tumors","year":2019,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Institutes of Health; Brain Tumour Charity; National Cancer Institute; KWF Kankerbestrijding; National Institute for Health and Care Research","keywords":"Refractory (planetary science); Pharmacokinetics; Medicine; Dabrafenib; Solid tumor; Mutation; Oncology; Internal medicine; Cancer; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005859234,0.0001238143,0.0002699927,0.00007494165,0.0000392123,0.00001517654,0.0001298074,0.00007649022,0.00003458556],"category_scores_gemma":[0.00009709056,0.00008958468,0.00002339781,0.0001428168,0.0001923915,0.00000778066,0.0001853473,0.0003309376,0.000001974846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001925752,"about_ca_system_score_gemma":0.0001773127,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009113012,"about_ca_topic_score_gemma":0.0001379416,"domain_scores_codex":[0.9981774,0.0003907769,0.0003757507,0.0004975774,0.0003018486,0.0002566433],"domain_scores_gemma":[0.9992659,0.00006855324,0.0000990268,0.00021558,0.0002020081,0.0001489057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007560905,0.005912325,0.9205705,0.00006815961,0.00009789551,0.00001325548,0.0002444758,0.000004725854,0.006464685,0.000001405705,0.0003289558,0.05873274],"study_design_scores_gemma":[0.02210949,0.0208645,0.951618,0.000141571,0.00002587396,0.000003492348,0.0001798019,0.00002721546,0.004646792,0.000004241858,0.0002153009,0.000163693],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979689,0.000466448,0.000002531858,0.00002757999,0.00005920657,0.001344182,0.00009042474,0.000002895099,0.0000378103],"genre_scores_gemma":[0.9992425,0.0003762229,0.0000185286,0.00006743438,0.00006685867,0.00006231016,0.00008145723,0.0000170119,0.00006769234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05856904,"threshold_uncertainty_score":0.3653157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05948289162910631,"score_gpt":0.4552782093316713,"score_spread":0.395795317702565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}