{"id":"W2972572345","doi":"10.1098/rsob.190156","title":"A consensus set of genetic vulnerabilities to ATR inhibition","year":2019,"lang":"en","type":"article","venue":"Open Biology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Institute of General Medical Sciences; National Cancer Institute; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Canada Research Chairs; Cancer Prevention and Research Institute of Texas; European Molecular Biology Organization","keywords":"Biology; DNA replication; DNA re-replication; Gene; DNA damage; DNA repair; Genetics; Eukaryotic DNA replication; DNA polymerase; DNA; CRISPR; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000194815,0.000105741,0.0001902027,0.00003372057,0.00002165551,0.00001042585,0.0002342602,0.0001496428,0.000222421],"category_scores_gemma":[0.0000734797,0.00009800807,0.00004959213,0.00005703689,0.00006284986,0.000001255164,0.0004189624,0.00004119363,0.0001260391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009226864,"about_ca_system_score_gemma":0.00006398835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001274734,"about_ca_topic_score_gemma":0.00006630563,"domain_scores_codex":[0.9991016,0.0001226617,0.0002088797,0.0003434455,0.00003896967,0.0001844281],"domain_scores_gemma":[0.9993636,0.00001953131,0.0000704533,0.0004180764,0.00007458505,0.00005376509],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001126468,0.00001701743,0.005811662,0.00001290946,0.00002285522,9.636803e-7,0.00004437711,0.00002734935,0.9905822,0.0009074544,0.001426582,0.00103398],"study_design_scores_gemma":[0.000645049,0.001642222,0.002177494,0.00001406056,0.000008387107,0.00002853383,0.0001759701,0.00001813315,0.9471602,0.001421547,0.04651406,0.000194293],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942431,0.00008360005,0.000203601,0.0002651117,0.0001896115,0.0005591995,0.00007575117,0.000006777491,0.004373197],"genre_scores_gemma":[0.9918852,0.000008786083,0.00517975,0.0004390859,0.00006205923,0.00003903711,0.0001146238,0.00001397975,0.002257423],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04508748,"threshold_uncertainty_score":0.3996653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01568794733237554,"score_gpt":0.2848628964743125,"score_spread":0.2691749491419369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}