{"id":"W2972572345","doi":"10.1098/rsob.190156","title":"A consensus set of genetic vulnerabilities to ATR inhibition","year":2019,"lang":"en","type":"article","venue":"Open Biology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Institute of General Medical Sciences; National Cancer Institute; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Canada Research Chairs; Cancer Prevention and Research Institute of Texas; European Molecular Biology Organization","keywords":"Biology; DNA replication; DNA re-replication; Gene; DNA damage; DNA repair; Genetics; Eukaryotic DNA replication; DNA polymerase; DNA; CRISPR; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002125651,0.001183019,0.0009311652,0.001188269,0.0004075768,0.0005106031,0.0004882959,0.0005899033,0.003152191],"category_scores_gemma":[0.0004947992,0.000198171,0.0005750593,0.0007267212,0.0004930748,0.0002841729,0.0008569742,0.0008484845,0.001043192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005392688,"about_ca_system_score_gemma":0.0008115747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005116189,"about_ca_topic_score_gemma":0.0006975207,"domain_scores_codex":[0.9994538,0.00003441512,0.00005132001,0.000168079,0.0002037323,0.00008856788],"domain_scores_gemma":[0.9993698,0.0001167277,0.0001981768,0.00008090965,0.0001113272,0.0001231705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0002164435,0.00005255887,0.005208621,0.000211329,0.00003518042,0.0007316798,0.0000403509,0.0006098698,0.9732422,0.001439281,0.0004129259,0.01779963],"study_design_scores_gemma":[0.00005204954,0.0007055879,0.06247403,0.00009258981,0.0002054194,0.008224615,0.0001907201,0.002701333,0.9034895,0.00281904,0.0189795,0.0000656535],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9478744,0.003069713,0.02542435,0.000643063,0.00008618345,0.0002501518,0.008981974,0.00155307,0.01211704],"genre_scores_gemma":[0.9605202,0.002695392,0.02135354,0.0005918038,0.00002580022,0.0003423653,0.00864253,0.0003664237,0.005461882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003152191,"threshold_uncertainty_score":0.01054513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01568794733237554,"score_gpt":0.2848628964743125,"score_spread":0.2691749491419369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}