{"id":"W2972575492","doi":"10.1101/771253","title":"Modeling Cancer Genomic Data in Yeast Reveals Selection Against ATM Function During Tumorigenesis","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Robertson Foundation; Stand Up To Cancer; National Ovarian Cancer Coalition; Yale University; Brandeis University; Memorial Sloan-Kettering Cancer Center; Ovarian Cancer Research Fund","keywords":"Rad50; Carcinogenesis; Genome instability; Biology; DNA repair; Chromosome instability; DNA damage; Mutation; Genetics; Cancer; Cancer research; Nijmegen breakage syndrome; Gene; DNA; Chromosome; DNA-binding protein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004492024,0.0004538361,0.0002587827,0.0005151122,0.0002377683,0.0004129896,0.0003395429,0.000172309,0.0005236541],"category_scores_gemma":[0.001478112,0.0001786363,0.0004883582,0.0006941709,0.0002059116,0.0001763626,0.0002024261,0.0002557042,0.0001062909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007182836,"about_ca_system_score_gemma":0.0006016865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01470895,"about_ca_topic_score_gemma":0.01477222,"domain_scores_codex":[0.9998139,0.00005847421,0.00001166437,0.00005546982,0.00004075985,0.00001974914],"domain_scores_gemma":[0.9994146,0.0003452002,0.00007723907,0.0000569055,0.00007949863,0.00002670115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0006964412,0.0001684514,0.07559438,0.0001571488,0.0002056957,0.0004977796,0.0002111035,0.8493986,0.05644534,0.00278003,0.0007043248,0.01314071],"study_design_scores_gemma":[0.00004155052,0.0002840952,0.02013762,0.00001107039,0.00009342326,0.0001760764,0.0002365745,0.9444937,0.03043782,0.001807651,0.002260722,0.00001981454],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895287,0.0001058279,0.008048647,0.00004174946,0.00000412348,0.00001855209,0.001549816,0.000255724,0.0004468868],"genre_scores_gemma":[0.9773883,0.0001781531,0.01714997,0.00001516264,0.000001258833,0.00002482984,0.004919479,0.00004283,0.0002799854],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01470895,"threshold_uncertainty_score":0.02924669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0164566834021067,"score_gpt":0.2298224789076918,"score_spread":0.2133657955055851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}