{"id":"W2972659374","doi":"10.1158/0008-5472.can-19-0274","title":"Diminished AHR Signaling Drives Human Acute Myeloid Leukemia Stem Cell Maintenance","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; McMaster University","funders":"Canadian Institutes of Health Research; Government of Canada; Ontario Institute for Cancer Research; Canadian Blood Services","keywords":"Aryl hydrocarbon receptor; Haematopoiesis; Stem cell; Myeloid leukemia; Cancer research; Signal transduction; Progenitor cell; Cell biology; Leukemia; Downregulation and upregulation; Myeloid; Biology; Immunology; Gene; Transcription factor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001186647,0.0001599604,0.0001538517,0.0002118797,0.0001307014,0.0002451282,0.0001066037,0.0001342377,0.001498753],"category_scores_gemma":[0.00007729257,0.00007064372,0.0001177357,0.0001624482,0.000180908,0.00007885232,0.000183906,0.0004552196,0.000386743],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002745573,"about_ca_system_score_gemma":0.0001955618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005498431,"about_ca_topic_score_gemma":0.0008179261,"domain_scores_codex":[0.9998343,0.00002483023,0.00001654785,0.00003076657,0.00006052918,0.00003298556],"domain_scores_gemma":[0.9999282,0.00001394445,0.00001801917,0.00001080672,0.00000986725,0.00001914185],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005907048,0.0000245806,0.0002137724,0.00001350736,0.000002027311,0.00001944778,0.00001387851,0.00006580205,0.9982858,0.0001647027,0.00005681067,0.001080594],"study_design_scores_gemma":[0.0000103627,0.0002176775,0.002001347,0.000002233353,0.000006805749,0.000101925,0.0000198741,0.0008435512,0.9938122,0.00003954001,0.002942763,0.000001790497],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993053,0.0005782367,0.003560175,0.00007960129,0.00001894371,0.00005375706,0.0007976729,0.0001694685,0.001689013],"genre_scores_gemma":[0.99604,0.000217608,0.001157783,0.00004071364,0.000007334023,0.00003273124,0.0006654815,0.00001364466,0.0018247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001498753,"threshold_uncertainty_score":0.005013824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0498136568298746,"score_gpt":0.3742121059018214,"score_spread":0.3243984490719468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}