{"id":"W2972659374","doi":"10.1158/0008-5472.can-19-0274","title":"Diminished AHR Signaling Drives Human Acute Myeloid Leukemia Stem Cell Maintenance","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; McMaster University","funders":"Canadian Institutes of Health Research; Government of Canada; Ontario Institute for Cancer Research; Canadian Blood Services","keywords":"Aryl hydrocarbon receptor; Haematopoiesis; Stem cell; Myeloid leukemia; Cancer research; Signal transduction; Progenitor cell; Cell biology; Leukemia; Downregulation and upregulation; Myeloid; Biology; Immunology; Gene; Transcription factor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.001953298,0.0003795546,0.0007400424,0.0006513587,0.0004457428,0.0001681334,0.0009748475,0.0003193137,0.002871211],"category_scores_gemma":[0.00006324339,0.000322992,0.0002286286,0.00128653,0.0005753079,0.0002780724,0.0006561193,0.002605448,0.002139068],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004225012,"about_ca_system_score_gemma":0.003077532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008114473,"about_ca_topic_score_gemma":0.00003396945,"domain_scores_codex":[0.993687,0.0003868584,0.0005543798,0.001163121,0.0021759,0.002032781],"domain_scores_gemma":[0.9962963,0.0004286899,0.0001151127,0.00138965,0.001048842,0.0007213625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007419494,0.00008483622,0.008056661,0.000573025,0.0002154687,0.0004456065,0.001306113,0.0000525893,0.9482576,0.0004777066,0.03561707,0.004171411],"study_design_scores_gemma":[0.009586651,0.001832401,0.01175754,0.001232058,0.0001273713,0.0001016724,0.004557625,0.0009162248,0.9109088,0.0003551116,0.05774718,0.0008774275],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9658015,0.0009422332,0.00004391668,0.00180735,0.0002423819,0.00186549,0.00004286628,0.0001548723,0.02909939],"genre_scores_gemma":[0.8710502,0.0008135042,0.0002732004,0.0003742443,0.0005740371,0.0003605683,0.00004214387,0.0001454467,0.1263667],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09726728,"threshold_uncertainty_score":0.9999222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0498136568298746,"score_gpt":0.3742121059018214,"score_spread":0.3243984490719468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}