{"id":"W2972678769","doi":"10.1016/j.molimm.2019.08.015","title":"Intragastric delivery of recombinant Lactococcus lactis displaying ectodomain of influenza matrix protein 2 (M2e) and neuraminidase (NA) induced focused mucosal and systemic immune responses in chickens","year":2019,"lang":"en","type":"article","venue":"Molecular Immunology","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"","keywords":"Ectodomain; Lactococcus lactis; Biology; Immune system; Neuraminidase; Virus; Virology; Viral matrix protein; Microbiology; Glycoprotein; Immunogenicity; Influenza vaccine; Antibody; Influenza A virus; Immunology; Molecular biology; Bacteria; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006609939,0.000278912,0.0009604337,0.0007835354,0.0000506631,0.00001234609,0.0001539274,0.0002569231,0.00001318116],"category_scores_gemma":[0.0009912133,0.0002506895,0.0000841697,0.0004764131,0.000327215,0.000102588,0.0003634845,0.0005910997,0.000007183681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001089381,"about_ca_system_score_gemma":0.0002098635,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007175744,"about_ca_topic_score_gemma":0.00001504796,"domain_scores_codex":[0.9974183,0.0006371963,0.0007716787,0.0004074544,0.0002673889,0.000497926],"domain_scores_gemma":[0.9985499,0.0003660805,0.0003257606,0.0005159317,0.0001753246,0.00006704122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004341589,0.0001404295,0.06494018,0.0007404888,0.0002692163,0.0002718476,0.0005279845,0.000002553342,0.925103,0.0001895081,0.000001163539,0.003472014],"study_design_scores_gemma":[0.01059255,0.002984288,0.5739211,0.001103907,0.00009361348,0.0003615238,0.0006103868,0.0001110839,0.409847,0.00006580607,0.0000298614,0.0002788363],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885654,0.00905019,0.00001223876,0.0001307312,0.00007449021,0.002090646,0.00001358734,0.00002468465,0.000038054],"genre_scores_gemma":[0.9992961,0.0002536524,0.000214327,0.00004123358,0.000004679166,0.0001100358,0.000004924377,0.00003897918,0.00003609904],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.515256,"threshold_uncertainty_score":0.9999945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02384177466438885,"score_gpt":0.3120760740388842,"score_spread":0.2882342993744954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}