{"id":"W2972678769","doi":"10.1016/j.molimm.2019.08.015","title":"Intragastric delivery of recombinant Lactococcus lactis displaying ectodomain of influenza matrix protein 2 (M2e) and neuraminidase (NA) induced focused mucosal and systemic immune responses in chickens","year":2019,"lang":"en","type":"article","venue":"Molecular Immunology","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"","keywords":"Ectodomain; Lactococcus lactis; Biology; Immune system; Neuraminidase; Virus; Virology; Viral matrix protein; Microbiology; Glycoprotein; Immunogenicity; Influenza vaccine; Antibody; Influenza A virus; Immunology; Molecular biology; Bacteria; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001120535,0.0004048219,0.0002104723,0.0001866921,0.0001385181,0.0001793217,0.0001506655,0.0003510604,0.0005455272],"category_scores_gemma":[0.00007616855,0.0001573047,0.0002258122,0.0000606473,0.0003279849,0.0002208667,0.0001283995,0.000683015,0.0001568538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003324483,"about_ca_system_score_gemma":0.0001701955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001055888,"about_ca_topic_score_gemma":0.001464107,"domain_scores_codex":[0.9999007,0.000009476238,0.000006110133,0.00003376739,0.0000151483,0.00003480574],"domain_scores_gemma":[0.9999245,0.00001558702,0.00002051078,0.000007333943,0.000007327455,0.0000247051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000361644,0.00005743001,0.00007629231,0.00002064118,0.000002102601,0.00003587971,0.00001838675,0.0000411119,0.9989607,0.00002840138,0.00001227512,0.0003850012],"study_design_scores_gemma":[0.00005365305,0.002726076,0.002539812,0.000005561666,0.00002303433,0.0001369155,0.00007250775,0.0006372168,0.9930428,0.00003487919,0.0007224815,0.000005048331],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983588,0.0003426666,0.0006745761,0.00004475009,0.00003167442,0.00001650308,0.00007671577,0.00002312804,0.0004311788],"genre_scores_gemma":[0.9965581,0.0002638153,0.000886803,0.00003635264,0.00001028429,0.00001795814,0.0001031107,0.000007839154,0.002115598],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001055888,"threshold_uncertainty_score":0.002412081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02384177466438885,"score_gpt":0.3120760740388842,"score_spread":0.2882342993744954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}