{"id":"W2972720803","doi":"10.1016/j.ebiom.2019.09.006","title":"Re-evaluating genetic variants identified in candidate gene studies of breast cancer risk using data from nearly 280,000 women of Asian and European ancestry","year":2019,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec; Université Laval; BC Cancer Agency; University of British Columbia; Queen's University","funders":"National Cancer Institute; Canadian Institutes of Health Research; Manchester Biomedical Research Centre; Horizon 2020 Framework Programme; National Institutes of Health; Government of Canada; Chonnam National University Hwasun Hospital; Chonnam National University; Ministry of Education, Culture, Sports, Science and Technology; National Research Foundation; National Research Foundation of Korea; Translation Centre for the Bodies of the European Union; European Commission; Ministère de l'Économie, de la Science et de l'Innovation - Québec; Foundation for the National Institutes of Health; Vanderbilt University Medical Center; Wellcome Trust; Cancer Research UK; National Institute for Health and Care Research; Ministry of Education, Science and Technology; Ministry of Education; Génome Québec; Canadian HIV Trials Network, Canadian Institutes of Health Research; National Research Foundation Singapore; Basic Research Laboratory; Vanderbilt University; Arab-British Chamber of Commerce; Genome Canada","keywords":"Genome-wide association study; Breast cancer; Genetic association; Candidate gene; Genetics; Biology; Medicine; Oncology; Cancer; Bioinformatics; Single-nucleotide polymorphism; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001125648,0.0001273113,0.0003943999,0.00007052884,0.0000347369,0.000004342161,0.0002274483,0.00007450685,0.00005408727],"category_scores_gemma":[0.0002231004,0.0001112781,0.0000179348,0.0001452307,0.0001505868,0.000005981015,0.0003075984,0.00007769385,0.000001384554],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002745138,"about_ca_system_score_gemma":0.00007572883,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003075049,"about_ca_topic_score_gemma":0.000431561,"domain_scores_codex":[0.9984337,0.0003065492,0.0004959569,0.0004091463,0.0001254947,0.0002291147],"domain_scores_gemma":[0.9988397,0.00004736716,0.000428529,0.0005353787,0.00009316239,0.0000558381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00005506707,0.00002405203,0.5901704,0.0000376036,0.000199311,0.000002488472,0.0006579075,0.000204834,0.4041169,1.584482e-7,0.0001318235,0.00439936],"study_design_scores_gemma":[0.001240799,0.0001691969,0.9931379,0.0001116519,0.00007238035,0.000004448198,0.001652838,0.002063542,0.001337331,0.00005130619,0.00004897498,0.0001096474],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940299,0.004459678,0.0001474426,0.0001335552,0.0002076782,0.0001434934,0.0008143978,0.000002447415,0.00006143076],"genre_scores_gemma":[0.9951687,0.002012538,0.002311547,0.00005960366,0.0001889359,0.000003653966,0.0001842159,0.00001621767,0.00005455894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4029674,"threshold_uncertainty_score":0.4648575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06597448408180497,"score_gpt":0.3682407954270033,"score_spread":0.3022663113451983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}