{"id":"W2972720803","doi":"10.1016/j.ebiom.2019.09.006","title":"Re-evaluating genetic variants identified in candidate gene studies of breast cancer risk using data from nearly 280,000 women of Asian and European ancestry","year":2019,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec; Université Laval; BC Cancer Agency; University of British Columbia; Queen's University","funders":"National Cancer Institute; Canadian Institutes of Health Research; Manchester Biomedical Research Centre; Horizon 2020 Framework Programme; National Institutes of Health; Government of Canada; Chonnam National University Hwasun Hospital; Chonnam National University; Ministry of Education, Culture, Sports, Science and Technology; National Research Foundation; National Research Foundation of Korea; Translation Centre for the Bodies of the European Union; European Commission; Ministère de l'Économie, de la Science et de l'Innovation - Québec; Foundation for the National Institutes of Health; Vanderbilt University Medical Center; Wellcome Trust; Cancer Research UK; National Institute for Health and Care Research; Ministry of Education, Science and Technology; Ministry of Education; Génome Québec; Canadian HIV Trials Network, Canadian Institutes of Health Research; National Research Foundation Singapore; Basic Research Laboratory; Vanderbilt University; Arab-British Chamber of Commerce; Genome Canada","keywords":"Genome-wide association study; Breast cancer; Genetic association; Candidate gene; Genetics; Biology; Medicine; Oncology; Cancer; Bioinformatics; Single-nucleotide polymorphism; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.05000118,0.001700495,0.002753546,0.00945593,0.001277498,0.002986962,0.002279552,0.001112835,0.002102308],"category_scores_gemma":[0.09978279,0.000883468,0.00607612,0.01419163,0.0009380012,0.00147884,0.001772435,0.001374617,0.0006526831],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007937658,"about_ca_system_score_gemma":0.001943325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01297954,"about_ca_topic_score_gemma":0.02829926,"domain_scores_codex":[0.9551859,0.01898567,0.01259218,0.007672404,0.004714352,0.0008495031],"domain_scores_gemma":[0.8944656,0.05770093,0.01113632,0.02469381,0.01095048,0.001052963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002007937,0.00007980135,0.8584738,0.00515124,0.06202499,0.002374444,0.001671751,0.001073106,0.01040557,0.0005941513,0.004981277,0.05116188],"study_design_scores_gemma":[0.0005348485,0.0005552956,0.9002558,0.001881705,0.05645469,0.003146954,0.001581864,0.001313588,0.004374685,0.002320568,0.02745879,0.0001210724],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7891279,0.1194879,0.0523605,0.003248654,0.001516626,0.0009827721,0.02681736,0.0006392709,0.005819041],"genre_scores_gemma":[0.9581175,0.009487148,0.0189596,0.001559773,0.0003852084,0.00060741,0.009895976,0.0002426261,0.0007448249],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05000118,"threshold_uncertainty_score":0.2644347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06597448408180497,"score_gpt":0.3682407954270033,"score_spread":0.3022663113451983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}