{"id":"W2972771389","doi":"10.1038/s41598-019-49261-3","title":"Electron cryomicroscopy observation of acyl carrier protein translocation in type I fungal fatty acid synthase","year":2019,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research; Princess Margaret Cancer Foundation; Natural Sciences and Engineering Research Council of Canada; Canadian Institute for Advanced Research; Cancer Research Institute","keywords":"Acyl carrier protein; Fatty acid synthase; Transferase; ATP synthase; Substrate (aquarium); Chemistry; Fatty acid; Stereochemistry; Active site; Acylation; Biochemistry; Fatty acid synthesis; Steric effects; Enzyme; Biosynthesis; Catalysis; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000792084,0.0001676849,0.00008604076,0.0001637958,0.0003865057,0.0001776279,0.0002076513,0.0003086177,0.001107599],"category_scores_gemma":[0.0001006348,0.0001420677,0.0001182839,0.000102665,0.0003063111,0.0002224721,0.000209493,0.0006978572,0.0002482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002647359,"about_ca_system_score_gemma":0.0001457409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001351612,"about_ca_topic_score_gemma":0.001265673,"domain_scores_codex":[0.9999757,0.000002239814,0.000001320432,0.000006136596,0.000007054084,0.000007639019],"domain_scores_gemma":[0.9999182,0.0000270306,0.00001182742,0.00001294705,0.00001592296,0.00001402056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001078646,0.00002814721,0.001058706,0.00004927863,0.000009260505,0.0007799206,0.00008743384,0.0004267165,0.9949985,0.0008952862,0.0002330611,0.001325876],"study_design_scores_gemma":[0.00006562273,0.0002825295,0.06215439,0.00005547797,0.00003884119,0.004026742,0.0003610592,0.01240455,0.9115979,0.0007791484,0.008205253,0.00002857063],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863761,0.001302351,0.006790489,0.0002851322,0.00003417688,0.00002027696,0.0003792691,0.00009932384,0.004712841],"genre_scores_gemma":[0.9902367,0.0007758666,0.006204793,0.00007758576,0.00001483102,0.00003078412,0.0003379126,0.00003551539,0.002285996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001351612,"threshold_uncertainty_score":0.003705323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01472378675772977,"score_gpt":0.2568406157192297,"score_spread":0.2421168289615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}