{"id":"W2972774762","doi":"10.1002/prp2.524","title":"Phenolic acid phenethylesters and their corresponding ketones: Inhibition of 5‐lipoxygenase and stability in human blood and HepaRG cells","year":2019,"lang":"en","type":"article","venue":"Pharmacology Research & Perspectives","topic":"Essential Oils and Antimicrobial Activity","field":"Agricultural and Biological Sciences","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Atlantic Cancer Research Institute; Université de Moncton","funders":"Natural Sciences and Engineering Research Council of Canada; New Brunswick Innovation Foundation; Fondation de la recherche en santé du Nouveau-Brunswick","keywords":"Ketone; Arachidonic acid; Biosynthesis; Chemistry; Caffeic acid phenethyl ester; Arachidonate 5-lipoxygenase; Leukotriene; Biochemistry; Lipoxygenase; Caffeic acid; Enzyme; Stereochemistry; Biology; Antioxidant; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008353886,0.000126617,0.0002517372,0.00006257735,0.0001904467,0.00004119645,0.00008052252,0.00009843263,0.0001890268],"category_scores_gemma":[0.0000269202,0.00006103943,0.00002982774,0.0002725731,0.0006593622,0.000210102,0.000208845,0.0003783792,0.000001337222],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002525859,"about_ca_system_score_gemma":0.0000124088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005482977,"about_ca_topic_score_gemma":0.0004050823,"domain_scores_codex":[0.9984431,0.0005301262,0.0001540701,0.0004389098,0.0001093107,0.0003245246],"domain_scores_gemma":[0.9992452,0.0004694357,0.00005631262,0.00003747744,0.00009335181,0.00009819539],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000163156,0.0003115312,0.01876007,0.00004917699,0.00002042983,0.000004184903,0.003342443,3.892457e-7,0.9761267,0.00009624714,0.0000151777,0.001110525],"study_design_scores_gemma":[0.0005629215,0.0003999195,0.05318239,0.00002638597,0.000007963567,0.000005112672,0.007252662,0.00003395104,0.9380301,0.0003494671,0.00003882915,0.0001102603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977214,0.0009678208,2.805894e-7,0.0006887541,0.00003604222,0.0003973388,0.00003969026,0.0000125087,0.0001361432],"genre_scores_gemma":[0.9989909,0.0008710616,0.000008764371,0.00002702823,0.00006332056,0.00001179496,0.000004019456,0.000001549223,0.0000215925],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03809652,"threshold_uncertainty_score":0.2489116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03629642873443912,"score_gpt":0.3153085772496362,"score_spread":0.2790121485151971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}