{"id":"W2972774762","doi":"10.1002/prp2.524","title":"Phenolic acid phenethylesters and their corresponding ketones: Inhibition of 5‐lipoxygenase and stability in human blood and HepaRG cells","year":2019,"lang":"en","type":"article","venue":"Pharmacology Research & Perspectives","topic":"Essential Oils and Antimicrobial Activity","field":"Agricultural and Biological Sciences","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Atlantic Cancer Research Institute; Université de Moncton","funders":"Natural Sciences and Engineering Research Council of Canada; New Brunswick Innovation Foundation; Fondation de la recherche en santé du Nouveau-Brunswick","keywords":"Ketone; Arachidonic acid; Biosynthesis; Chemistry; Caffeic acid phenethyl ester; Arachidonate 5-lipoxygenase; Leukotriene; Biochemistry; Lipoxygenase; Caffeic acid; Enzyme; Stereochemistry; Biology; Antioxidant; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001452231,0.0002560247,0.0001571741,0.0001301847,0.00008436072,0.0001088271,0.00008551082,0.000100076,0.0008900384],"category_scores_gemma":[0.0001240589,0.00006073058,0.000163425,0.0001314686,0.0001098104,0.00008990625,0.00008865204,0.0001700473,0.0002001648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001421906,"about_ca_system_score_gemma":0.0001278459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001676099,"about_ca_topic_score_gemma":0.002035591,"domain_scores_codex":[0.9999328,0.00002084451,0.000006395489,0.0000105249,0.00001607026,0.00001335423],"domain_scores_gemma":[0.9999459,0.00001194742,0.00001575702,0.000006533468,0.00001150715,0.000008361374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002383836,0.00003969443,0.0001883361,0.00005650763,0.00001069966,0.00005524814,0.00003108819,0.0001449426,0.9962902,0.00003071429,0.00003489221,0.00287937],"study_design_scores_gemma":[0.00002327592,0.0007971648,0.003529884,0.00000635009,0.00002688722,0.0001034482,0.00002368039,0.0004239233,0.9935479,0.00001972211,0.001492904,0.000004836606],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918034,0.005119268,0.001493572,0.00005219806,0.00001514726,0.00003188251,0.0003412526,0.00002579304,0.001117388],"genre_scores_gemma":[0.994831,0.001966998,0.001153938,0.00002947079,0.000007876085,0.00001659382,0.0003625498,0.000005157618,0.001626515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001676099,"threshold_uncertainty_score":0.003332675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03629642873443912,"score_gpt":0.3153085772496362,"score_spread":0.2790121485151971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}