{"id":"W2972791272","doi":"10.1101/764217","title":"TIGIT is upregulated by HIV-1 infection and marks a highly functional adaptive and mature subset of natural killer cells","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Université de Montréal; Hôpital Maisonneuve-Rosemont; Université Laval; Institut National de Santé Publique du Québec","funders":"National Institute on Drug Abuse; Canadian Institutes of Health Research; National Institutes of Health; Styrelsen för Internationellt Utvecklingssamarbete; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation","keywords":"TIGIT; Immunology; Cytotoxic T cell; Biology; Downregulation and upregulation; Population; Natural killer cell; Interleukin 21; Cancer research; Cell biology; Immune system; CD8; Medicine; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008160371,0.0002106339,0.0001999319,0.0004093618,0.0001595714,0.0004344338,0.0001473303,0.0002602331,0.002398147],"category_scores_gemma":[0.000158665,0.000145598,0.0001627667,0.000254845,0.0001758882,0.0001308373,0.0001893903,0.0002874334,0.0003102695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002102376,"about_ca_system_score_gemma":0.0000805113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002932635,"about_ca_topic_score_gemma":0.0002357082,"domain_scores_codex":[0.9998661,0.00001364747,0.000009024317,0.00004085713,0.00002691051,0.00004335561],"domain_scores_gemma":[0.9999167,0.00001387526,0.00002803371,0.00001011569,0.00001087625,0.00002047691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002454544,0.00001369411,0.005082551,0.00002382237,0.000005578697,0.0001289587,0.00002632436,0.00002005878,0.9928934,0.00003150731,0.00002717346,0.001501379],"study_design_scores_gemma":[0.00004588722,0.001284332,0.4038851,0.00002467329,0.00007336261,0.004713914,0.0003751999,0.0008318447,0.5850028,0.0002023823,0.003545383,0.00001513127],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980583,0.0007345105,0.0003043106,0.00001805715,0.000005797168,0.00001114446,0.0001853661,0.00001705614,0.000665386],"genre_scores_gemma":[0.9979258,0.0002812183,0.0006097239,0.00002878859,0.00001239205,0.00002011886,0.0003788123,0.00000633929,0.0007368638],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002398147,"threshold_uncertainty_score":0.008022547,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006137929876882829,"score_gpt":0.1799808555168214,"score_spread":0.1738429256399386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}