{"id":"W2972847538","doi":"10.1182/bloodadvances.2019000338","title":"Mitigation of T-cell dependent immunogenicity by reengineering factor VIIa analogue","year":2019,"lang":"en","type":"article","venue":"Blood Advances","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Oak Ridge Institute for Science and Education; McGill University; U.S. Department of Energy","keywords":"Immunogenicity; Peripheral blood mononuclear cell; Pharmacology; Recombinant DNA; Thrombin; Medicine; Antibody; Cell; Immunology; Chemistry; Biochemistry; In vitro; Gene; Platelet","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002226971,0.0002824967,0.0001884512,0.0001218746,0.00008098532,0.0002695126,0.0001796734,0.0002050006,0.0004460931],"category_scores_gemma":[0.000262676,0.00007225875,0.0001816034,0.00008942188,0.0001609996,0.0001488552,0.0001671627,0.0004456772,0.0001702819],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001402141,"about_ca_system_score_gemma":0.0001193557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001729372,"about_ca_topic_score_gemma":0.0001780376,"domain_scores_codex":[0.9997845,0.00005626335,0.0000155043,0.00004484037,0.00005705222,0.00004174245],"domain_scores_gemma":[0.9998871,0.00001882945,0.00004880478,0.0000171917,0.00001749545,0.0000106188],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005687698,0.000035104,0.0001877211,0.00001393927,0.000004935136,0.00003495828,0.00001064853,0.0004078525,0.9962412,0.0001095338,0.00002170451,0.002875417],"study_design_scores_gemma":[0.00001610548,0.0007411875,0.0008352288,0.000002840537,0.00001360041,0.0002061508,0.000008638436,0.001686458,0.9949198,0.00005164377,0.001514622,0.000003726118],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984005,0.0007524769,0.0137951,0.00005797672,0.00001677501,0.00006531734,0.00005726669,0.0000546405,0.001195407],"genre_scores_gemma":[0.9943479,0.000321479,0.004510672,0.00004551305,0.000008047079,0.00002424949,0.00008776853,0.00001260656,0.0006418011],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004460931,"threshold_uncertainty_score":0.001492262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007554641355725461,"score_gpt":0.2556766659815073,"score_spread":0.2481220246257819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}