{"id":"W2972847538","doi":"10.1182/bloodadvances.2019000338","title":"Mitigation of T-cell dependent immunogenicity by reengineering factor VIIa analogue","year":2019,"lang":"en","type":"article","venue":"Blood Advances","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Oak Ridge Institute for Science and Education; McGill University; U.S. Department of Energy","keywords":"Immunogenicity; Peripheral blood mononuclear cell; Pharmacology; Recombinant DNA; Thrombin; Medicine; Antibody; Cell; Immunology; Chemistry; Biochemistry; In vitro; Gene; Platelet","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005493966,0.00008990383,0.0001906944,0.00005513729,0.00002035823,0.000004603388,0.00006287908,0.00004718746,0.0001294327],"category_scores_gemma":[0.00001847684,0.00006890525,0.00006287944,0.0001028012,0.00002283389,0.00009649387,0.00002055054,0.00009078936,0.00003970366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000198941,"about_ca_system_score_gemma":0.00003124595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001942182,"about_ca_topic_score_gemma":0.00000395138,"domain_scores_codex":[0.9992628,0.00001356144,0.0001582141,0.0001517485,0.0002502344,0.000163426],"domain_scores_gemma":[0.9996206,0.00004293587,0.00004657894,0.0001744909,0.00005180077,0.00006355554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004200661,0.0002151283,0.1393258,0.0001864771,0.00006879127,0.000006849362,0.00005073692,0.00001746007,0.8584359,0.000008774461,0.00001834979,0.001623773],"study_design_scores_gemma":[0.001739639,0.0003464668,0.01847489,0.00006756734,0.00005045229,0.000006776052,0.00006220485,0.00007548978,0.9780145,0.00001575075,0.001069056,0.00007719109],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923166,0.005676445,0.00005469514,0.00007269793,0.0000664708,0.0002794318,0.00003223167,0.0000251718,0.001476229],"genre_scores_gemma":[0.9968452,0.0006450791,0.0005603384,0.00001030229,0.0000313351,0.000006764991,0.00005789902,0.00001067773,0.001832429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1208509,"threshold_uncertainty_score":0.2809874,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007554641355725461,"score_gpt":0.2556766659815073,"score_spread":0.2481220246257819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}