{"id":"W2972858675","doi":"10.1093/nar/gkz784","title":"CSB interacts with BRCA1 in late S/G2 to promote MRN- and CtIP-mediated DNA end resection","year":2019,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Université Laval; University of Toronto; McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Biology; DNA repair; Homologous recombination; Histone; DNA damage; Cell biology; Rad50; Genome instability; DNA; Phosphorylation; Cell cycle; Genetics; Molecular biology; DNA-binding protein; Cell; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008809501,0.0003055927,0.0001540214,0.0001914673,0.0002345422,0.0002993502,0.0001659677,0.0002462162,0.002664803],"category_scores_gemma":[0.00007533508,0.0001646451,0.0002435533,0.0001089474,0.0001930703,0.0001933798,0.0002778884,0.0003076961,0.001317845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005633265,"about_ca_system_score_gemma":0.0002640706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001213883,"about_ca_topic_score_gemma":0.001784451,"domain_scores_codex":[0.9999001,0.00001096134,0.000004714734,0.00002406812,0.00002842207,0.00003172605],"domain_scores_gemma":[0.9999161,0.000009554626,0.00002362633,0.000008192904,0.000006434475,0.00003609467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008235541,0.00001080202,0.0002615022,0.00002901924,0.000004372731,0.0000313716,0.000006159792,0.00005770203,0.9987319,0.00008497063,0.0000623622,0.0006373655],"study_design_scores_gemma":[0.0000115193,0.00006226665,0.008938693,0.000006654272,0.000005817093,0.0001503433,0.00002152451,0.000959813,0.9863765,0.00005572989,0.003406193,0.000004959563],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927735,0.002098297,0.002422381,0.0001379789,0.00002284051,0.00001499337,0.000289272,0.00009041053,0.002150363],"genre_scores_gemma":[0.992793,0.0007071672,0.001498927,0.00006649651,0.000007255973,0.00001785232,0.0008631223,0.00003327254,0.004013071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002664803,"threshold_uncertainty_score":0.008914649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01684759391636453,"score_gpt":0.30138691702858,"score_spread":0.2845393231122155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}