{"id":"W2972861243","doi":"10.1124/mol.119.116483","title":"Probing the CB1 Cannabinoid Receptor Binding Pocket with AM6538, a High-Affinity Irreversible Antagonist","year":2019,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute on Drug Abuse; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Antagonist; Cannabinoid; Chemistry; Cannabinoid receptor; Receptor; Stereochemistry; Biophysics; Biochemistry; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005278535,0.0002908457,0.0004367897,0.0002120525,0.0002755271,0.00006194902,0.0003415236,0.0001467633,0.003561195],"category_scores_gemma":[0.00003166516,0.0001964371,0.0001457668,0.0006663797,0.0002744428,0.00008451387,0.000202349,0.0007936044,0.0006412462],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003035766,"about_ca_system_score_gemma":0.0007318882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003092313,"about_ca_topic_score_gemma":0.00001768803,"domain_scores_codex":[0.9975564,0.0002634543,0.0002724922,0.0005719845,0.0005193134,0.0008163822],"domain_scores_gemma":[0.9988674,0.00002329539,0.0001206079,0.000466394,0.0002400961,0.0002822196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008332616,0.0002038311,0.001920806,0.000163783,0.0002436497,0.0003158528,0.0002062563,0.00007097857,0.8326417,0.0002212016,0.1625356,0.000643109],"study_design_scores_gemma":[0.005851942,0.00143982,0.001948031,0.00006314063,0.0002872807,0.0003441221,0.0003999685,0.0001806373,0.6306599,0.00001776389,0.3584121,0.0003952948],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9601744,0.0003437963,0.00005841612,0.03421874,0.0006899534,0.001754724,0.00003562843,0.00009061248,0.00263368],"genre_scores_gemma":[0.9741255,0.0000461065,0.000227769,0.005648712,0.0002286497,0.0002402497,0.00009281091,0.00007776663,0.01931242],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2019817,"threshold_uncertainty_score":0.9973497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009977861646587132,"score_gpt":0.2821745025047245,"score_spread":0.2721966408581374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}