{"id":"W2972875166","doi":"10.1038/s41598-019-49337-0","title":"MARK4 protein can explore the active-like conformations in its non-phosphorylated state","year":2019,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Shiraz University of Medical Sciences; Ministère de l'Économie, de la Science et de l'Innovation - Québec; Compute Canada; Polytechnique Montréal; Shiraz University; McGill University","keywords":"Phosphorylation; Microtubule; Biophysics; Kinase; Chemistry; Protein kinase A; Protein structure; Crystallography; Cell biology; Biochemistry; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008450484,0.0003206255,0.0002318199,0.0001029722,0.0003965792,0.0003323396,0.0005609,0.0003721401,0.002237325],"category_scores_gemma":[0.0001919958,0.000167088,0.0003365343,0.00009782104,0.000346159,0.0006523494,0.0002576149,0.0004060272,0.0002435585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000464037,"about_ca_system_score_gemma":0.0004787019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00288285,"about_ca_topic_score_gemma":0.002311873,"domain_scores_codex":[0.9999737,0.000002659188,8.214143e-7,0.000007225182,0.000006060309,0.000009514711],"domain_scores_gemma":[0.9999619,0.000007911867,0.000006253719,0.000005021363,0.000006977566,0.0000119834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001070875,0.0005759556,0.02056323,0.0006008132,0.0003628079,0.001728919,0.0006146864,0.5550612,0.3694077,0.02631087,0.002318801,0.02138404],"study_design_scores_gemma":[0.0001614342,0.0006095038,0.006660077,0.0000243719,0.00009464207,0.0002612447,0.0003000041,0.926863,0.05299737,0.006568429,0.005410235,0.00004965636],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884008,0.0001609475,0.007744965,0.00008739041,0.00001947619,0.00001022071,0.0001351429,0.000139681,0.003301417],"genre_scores_gemma":[0.9950396,0.0001809,0.003269693,0.00002342995,0.000003684497,0.00001845452,0.0004301053,0.00004612608,0.0009879243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00288285,"threshold_uncertainty_score":0.007484555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007620994527738282,"score_gpt":0.2220761695352671,"score_spread":0.2144551750075288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}