{"id":"W2972899190","doi":"10.1038/s41467-019-12096-7","title":"p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia Hospital; Douglas Mental Health University Institute; University of British Columbia","funders":"Canadian Institutes of Health Research; National Health Research Institutes; CIHR Skin Research Training Centre; China Medical University Hospital; Yale University; Government of Canada; China Medical University; Heart and Stroke Foundation of Canada","keywords":"AMPA receptor; Homomeric; Long-term potentiation; Cell biology; Postsynaptic potential; Glutamate receptor; Synaptic plasticity; Neurotransmission; Postsynaptic density; Intracellular; Excitatory postsynaptic potential; Chemistry; Biology; Receptor; Neuroscience; Biochemistry; Gene; Protein subunit","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001426142,0.000270692,0.0002551037,0.0002029746,0.0002849523,0.0005756865,0.0004053469,0.0004113902,0.001747174],"category_scores_gemma":[0.0002969554,0.0001675433,0.0003282014,0.0001927862,0.0004000468,0.0003878362,0.0004342039,0.0007239808,0.0007901558],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002101144,"about_ca_system_score_gemma":0.0002117198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003199894,"about_ca_topic_score_gemma":0.0002871819,"domain_scores_codex":[0.9998167,0.00002333171,0.00002028401,0.00004557222,0.00004853923,0.00004559974],"domain_scores_gemma":[0.9998485,0.00002983821,0.00005315231,0.00002595249,0.00001037942,0.00003220489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006438268,0.00009918401,0.0006430437,0.00007399282,0.00001144334,0.000530167,0.00004709338,0.0001189548,0.9914904,0.0007181568,0.0002568377,0.005366851],"study_design_scores_gemma":[0.00005120748,0.0002194547,0.01278281,0.00001487084,0.00001648013,0.0008192447,0.0001045753,0.001414485,0.9795024,0.0003200196,0.004744106,0.00001016117],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918344,0.001893413,0.003401762,0.0001674371,0.00007361048,0.00001366095,0.0003175986,0.000111669,0.00218637],"genre_scores_gemma":[0.9946452,0.001167677,0.0009997515,0.00005403482,0.00001411055,0.0000389823,0.0004848142,0.00004127746,0.002554159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001747174,"threshold_uncertainty_score":0.005844831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04055417921588442,"score_gpt":0.3459374778040631,"score_spread":0.3053832985881787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}