{"id":"W2972910926","doi":"10.1111/bph.14867","title":"Isoniazid and host immune system interactions: A proposal for a novel comprehensive mode of action","year":2019,"lang":"en","type":"review","venue":"British Journal of Pharmacology","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Toronto General Hospital; University of Toronto; Canadian Institute for Advanced Research","funders":"Diabetes Canada","keywords":"Isoniazid; Mycobacterium tuberculosis; Mode of action; Microbiology; Tuberculosis; Immune system; Antibiotics; Latent tuberculosis; Biology; Immunology; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007037216,0.0009879495,0.001410085,0.001967719,0.0003252872,0.001347491,0.001232414,0.001634795,0.00294638],"category_scores_gemma":[0.0004026982,0.0002964869,0.0006683259,0.001643646,0.001015859,0.002711101,0.0006612347,0.002411113,0.001217819],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009006947,"about_ca_system_score_gemma":0.001500861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007048136,"about_ca_topic_score_gemma":0.001230103,"domain_scores_codex":[0.9998713,0.0000256581,0.00001701113,0.00002826437,0.00003960626,0.00001822391],"domain_scores_gemma":[0.9998682,0.0000537916,0.00002038185,0.000006172236,0.00003460246,0.00001688831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002338574,0.0001746953,0.0003166326,0.04221521,0.0001972427,0.0006219459,0.0002893346,0.0007660161,0.00514198,0.04034893,0.03209474,0.8775994],"study_design_scores_gemma":[0.00007955563,0.0002961587,0.001039291,0.005868621,0.0002259973,0.00191968,0.0001935918,0.0003278437,0.0006189659,0.0129402,0.9764611,0.00002911269],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002164728,0.9979706,0.000234826,0.0005798842,0.00030255,0.000006183325,0.00000918989,0.000009042636,0.0006712743],"genre_scores_gemma":[0.001481744,0.9970486,0.0003712728,0.0002859411,0.0002045951,0.00001204775,0.00001522388,0.000001134854,0.0005796001],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00294638,"threshold_uncertainty_score":0.009856641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1168589438657273,"score_gpt":0.4728220102788572,"score_spread":0.3559630664131299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}