{"id":"W2972931607","doi":"10.3390/nu11092179","title":"Docosahexaenoic and Eicosapentaenoic Acids Prevent Altered-Muc2 Secretion Induced by Palmitic Acid by Alleviating Endoplasmic Reticulum Stress in LS174T Goblet Cells","year":2019,"lang":"en","type":"article","venue":"Nutrients","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Agence Nationale de la Recherche; University of Alberta","keywords":"Lipotoxicity; Docosahexaenoic acid; Eicosapentaenoic acid; Endoplasmic reticulum; Endocrinology; Arachidonic acid; Internal medicine; Unfolded protein response; Mucin; Biology; Chemistry; Fatty acid; Biochemistry; Polyunsaturated fatty acid; Medicine; Insulin resistance; Insulin","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001751605,0.0003820924,0.0003757591,0.0001672898,0.0001222309,0.0002132858,0.0001711965,0.000266426,0.001121174],"category_scores_gemma":[0.0001100135,0.0001047076,0.0002815945,0.000155868,0.0001990633,0.0002335265,0.0002257568,0.000426606,0.0003304364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001481916,"about_ca_system_score_gemma":0.0002391798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007603535,"about_ca_topic_score_gemma":0.001179291,"domain_scores_codex":[0.9998974,0.00002401956,0.00001625062,0.00001715705,0.00001854896,0.00002669006],"domain_scores_gemma":[0.9999105,0.00001413733,0.00002035824,0.00001575489,0.00001375149,0.00002549595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006575508,0.0000500593,0.0001357329,0.00004680623,0.00000585404,0.0000479843,0.00001564596,0.00002802256,0.998037,0.0000216492,0.0000223614,0.0009313992],"study_design_scores_gemma":[0.00009797113,0.001722662,0.007135415,0.00001081089,0.00002524731,0.0001304481,0.00007420329,0.0003074497,0.9878401,0.00003282658,0.002617158,0.000005736789],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946726,0.002561359,0.001127795,0.0001580738,0.0000530496,0.00003636797,0.0004066982,0.00005072824,0.0009333715],"genre_scores_gemma":[0.9912566,0.001904871,0.00266796,0.0001387531,0.0000187293,0.00007546822,0.0007835549,0.00002047959,0.003133696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001121174,"threshold_uncertainty_score":0.003750682,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003841842085055588,"score_gpt":0.2165486744439084,"score_spread":0.2127068323588528,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}