{"id":"W2972934724","doi":"10.1530/ey.16.11.1","title":"Genetic architecture of human thinness compared to severe obesity","year":2019,"lang":"en","type":"article","venue":"Yearbook of pediatric endocrinology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Population and Public Health","funders":"Common Fund; National Cancer Institute; National Institute on Drug Abuse; National Institute of Mental Health; University of Warwick; National Heart, Lung, and Blood Institute; NIHR Cambridge Biomedical Research Centre; Economic and Social Research Council; National Institutes of Health; NIH Office of the Director; Israel Science Foundation; National Institute of Neurological Disorders and Stroke; National Institute for Health and Care Research; Understanding Society; Medical Research Council; National Human Genome Research Institute; Wellcome Trust; University of Essex","keywords":"Genetic architecture; Obesity; Inheritance (genetic algorithm); Cohort; Association (psychology); Genetic association; Genome-wide association study; Psychology; Demography; Biology; Medicine; Genetics; Single-nucleotide polymorphism; Genotype; Internal medicine; Endocrinology; Quantitative trait locus; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003124761,0.0003261166,0.0002520024,0.001533739,0.0003772795,0.0005307305,0.0001783803,0.0003126957,0.003070762],"category_scores_gemma":[0.00107057,0.0001826118,0.0002887319,0.001398206,0.0004772125,0.0001654294,0.0005297693,0.0004800349,0.0002216447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001079052,"about_ca_system_score_gemma":0.0001711201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001505116,"about_ca_topic_score_gemma":0.001188635,"domain_scores_codex":[0.9996357,0.0001129038,0.00002613743,0.0001350107,0.00005687425,0.00003344179],"domain_scores_gemma":[0.9993234,0.0001741244,0.0002720928,0.00008228428,0.00004460223,0.0001035447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001291383,0.00007288856,0.9139364,0.0001377763,0.0007207553,0.001530784,0.000654936,0.0004488986,0.05319642,0.001978532,0.0006358809,0.02539554],"study_design_scores_gemma":[0.00001558661,0.0001007397,0.9947357,0.0000251068,0.0001680619,0.001580965,0.0001216688,0.0002184039,0.0007285039,0.001624231,0.0006695988,0.00001148564],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947973,0.002028306,0.001019441,0.000212105,0.0000290441,0.000009839104,0.000454114,0.00002886297,0.001420783],"genre_scores_gemma":[0.997841,0.0007837892,0.0005470504,0.00005305895,0.00005491221,0.000006989912,0.0003049857,0.00001826913,0.0003898311],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003070762,"threshold_uncertainty_score":0.01027274,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0101723976765799,"score_gpt":0.2549909651595193,"score_spread":0.2448185674829394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}