{"id":"W2972979794","doi":"10.1073/pnas.1906102116","title":"Human papillomavirus E7 oncoprotein targets RNF168 to hijack the host DNA damage response","year":2019,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cervical Cancer and HPV Research","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Université Laval","funders":"Institute of Cancer Research; National Cancer Institute; Government of Canada; Institute of Infection and Immunity; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Genome instability; DNA damage; Biology; Ubiquitin; DNA repair; Ubiquitin ligase; Cancer research; DNA; Cancer; Mechanism (biology); Genetics; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001141066,0.0003815462,0.000167248,0.000190419,0.0001895363,0.0003034724,0.0001426673,0.0003954349,0.00181975],"category_scores_gemma":[0.0001086993,0.0001155195,0.0001701691,0.00007397804,0.0002428873,0.0001853888,0.0002662981,0.000375765,0.000891229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004101189,"about_ca_system_score_gemma":0.0002542175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003661701,"about_ca_topic_score_gemma":0.00073679,"domain_scores_codex":[0.9999137,0.00001559461,0.000004406354,0.00001767007,0.00002779277,0.0000208298],"domain_scores_gemma":[0.9999387,0.000008436978,0.00001283815,0.000007860768,0.000009621759,0.0000224628],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004028764,0.00001726754,0.0003582973,0.00003005541,0.000004333722,0.00008174606,0.000006498667,0.00003249656,0.9959475,0.0002628698,0.00007973979,0.003138918],"study_design_scores_gemma":[0.000008617556,0.0001328618,0.003603612,0.000007879908,0.000007482936,0.0005617411,0.00003482364,0.0006310883,0.9874997,0.000145552,0.007363086,0.00000350953],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9740568,0.008489717,0.00800977,0.0003957643,0.000108083,0.00005386788,0.0001861107,0.0002102398,0.008489644],"genre_scores_gemma":[0.987176,0.00235701,0.003912252,0.0001000883,0.00001760387,0.00002296398,0.0002739983,0.00002421221,0.006115886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00181975,"threshold_uncertainty_score":0.00608772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05971407911492196,"score_gpt":0.3835398329655017,"score_spread":0.3238257538505798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}