{"id":"W2973010902","doi":"10.1159/000502240","title":"Autologous Cell Therapy for Aged Human Skin: A Randomized, Placebo-Controlled, Phase-I Study","year":2019,"lang":"en","type":"article","venue":"Skin Pharmacology and Physiology","topic":"Skin Protection and Aging","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Achieve Life Sciences (Canada)","funders":"Leibniz-Gemeinschaft","keywords":"Medicine; Placebo; Clinical endpoint; Lumican; Adverse effect; Fibroblast; Extracellular matrix; Dermal fibroblast; Homeostasis; Downregulation and upregulation; Internal medicine; Pathology; Gastroenterology; Urology; Randomized controlled trial; Biology; Cell culture; Decorin; Proteoglycan; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009073294,0.0002963264,0.001481621,0.0001807997,0.0002634575,0.000009963735,0.0001164993,0.000205269,0.001634119],"category_scores_gemma":[0.00003206666,0.000217831,0.0003032715,0.0001017838,0.0002435788,0.00004639125,0.00004547908,0.0004214752,0.00004936762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002348299,"about_ca_system_score_gemma":0.00005145108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002404268,"about_ca_topic_score_gemma":0.000001934383,"domain_scores_codex":[0.997672,0.0008003718,0.0004524015,0.0005622737,0.0000852744,0.0004276672],"domain_scores_gemma":[0.9983835,0.001009926,0.0002224511,0.0001994648,0.00007404898,0.000110598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5425927,0.002153943,0.0003645165,0.00008283334,0.001007036,0.00002109359,0.001319546,0.00001399226,0.4468986,0.0001012709,0.002187186,0.003257294],"study_design_scores_gemma":[0.9607986,0.003931615,0.002259852,0.000009038146,0.0004891059,0.00005697137,0.0003668523,0.001020805,0.02771056,0.0008489896,0.002253284,0.0002543326],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861701,0.0006641582,0.0001052273,0.000429743,0.001136059,0.009997294,0.000005615425,0.0001052808,0.001386559],"genre_scores_gemma":[0.9924294,0.000101888,0.00008218319,0.002850029,0.000500149,0.001904402,0.0000244668,0.00003279741,0.002074697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.419188,"threshold_uncertainty_score":0.9992785,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01489117601489035,"score_gpt":0.3437471077666726,"score_spread":0.3288559317517822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}