{"id":"W2973010902","doi":"10.1159/000502240","title":"Autologous Cell Therapy for Aged Human Skin: A Randomized, Placebo-Controlled, Phase-I Study","year":2019,"lang":"en","type":"article","venue":"Skin Pharmacology and Physiology","topic":"Skin Protection and Aging","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Achieve Life Sciences (Canada)","funders":"Leibniz-Gemeinschaft","keywords":"Medicine; Placebo; Clinical endpoint; Lumican; Adverse effect; Fibroblast; Extracellular matrix; Dermal fibroblast; Homeostasis; Downregulation and upregulation; Internal medicine; Pathology; Gastroenterology; Urology; Randomized controlled trial; Biology; Cell culture; Decorin; Proteoglycan; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002575742,0.001500736,0.002831209,0.0004455317,0.0004531166,0.001025313,0.0008457409,0.001679914,0.005935355],"category_scores_gemma":[0.001127424,0.0005479465,0.001380787,0.000518035,0.001232098,0.000759869,0.000298782,0.001798773,0.001041361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005012247,"about_ca_system_score_gemma":0.001358995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000493857,"about_ca_topic_score_gemma":0.000994919,"domain_scores_codex":[0.9993303,0.0003127331,0.00004566217,0.0001380146,0.00007451802,0.00009885441],"domain_scores_gemma":[0.9991698,0.0001827286,0.0002224438,0.00009627504,0.00009131843,0.0002373119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9628137,0.01756539,0.0004881664,0.0008726646,0.0005561597,0.00003964798,0.00003725951,0.00015497,0.007932236,0.00006003143,0.0004176217,0.009062172],"study_design_scores_gemma":[0.8366819,0.1603496,0.001203822,0.00003428369,0.0003300832,0.00002334442,0.00001502533,0.0001193982,0.0006813175,0.00005270609,0.0005008735,0.000007667298],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9731021,0.008674904,0.001339548,0.0004963473,0.0006749823,0.01293584,0.001250587,0.0001261065,0.001399601],"genre_scores_gemma":[0.9603362,0.007917943,0.003307209,0.001636629,0.001074009,0.01884777,0.001381138,0.00003456046,0.005464506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005935355,"threshold_uncertainty_score":0.01985568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01489117601489035,"score_gpt":0.3437471077666726,"score_spread":0.3288559317517822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}