{"id":"W2973096717","doi":"10.1158/1078-0432.ccr-19-1587","title":"Transcriptomic Heterogeneity of Androgen Receptor Activity Defines a <i>de novo</i> low AR-Active Subclass in Treatment Naïve Primary Prostate Cancer","year":2019,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"Decipher Biosciences (Canada)","funders":"National Institutes of Health; National Cancer Institute; Prostate Cancer Foundation; U.S. Department of Defense","keywords":"Prostate cancer; Androgen receptor; Medicine; Oncology; Prostatectomy; Docetaxel; Internal medicine; Cancer; Androgen deprivation therapy; Biochemical recurrence; Androgen; Cancer research; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000252423,0.0001412308,0.0003260293,0.0004227176,0.0002466073,0.00064964,0.0002026277,0.0001670182,0.001094726],"category_scores_gemma":[0.0004767167,0.0001001356,0.0002169632,0.0004551022,0.0002577016,0.0001422646,0.0002630507,0.0002858066,0.0002347219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002642663,"about_ca_system_score_gemma":0.0002015992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001493873,"about_ca_topic_score_gemma":0.00192136,"domain_scores_codex":[0.9997913,0.00003047702,0.00001586199,0.00007845923,0.00004348425,0.00004043468],"domain_scores_gemma":[0.9996495,0.00006221424,0.0001461218,0.00004056845,0.00004611445,0.00005551272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000728976,0.00006762394,0.9127227,0.00005314864,0.0001359097,0.0001471972,0.0001409619,0.0001499354,0.0793504,0.0001186439,0.0003895874,0.005994795],"study_design_scores_gemma":[0.000009171772,0.00009661981,0.9966691,0.000003457126,0.00003239205,0.0002990667,0.0001122006,0.0002702165,0.002071634,0.00007600183,0.0003566827,0.000003538425],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986123,0.0002125476,0.0002050164,0.00002808941,0.000002226143,0.000007969548,0.0006122236,0.00000837271,0.0003111811],"genre_scores_gemma":[0.9985947,0.00005585956,0.00008494827,0.00002990679,0.000004644531,0.000006811119,0.001102162,0.000004657123,0.0001162913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001493873,"threshold_uncertainty_score":0.003662229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.147179231300564,"score_gpt":0.4828978287919585,"score_spread":0.3357185974913944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}