{"id":"W2973112096","doi":"10.1016/j.scr.2019.101577","title":"An integration-free iPSC line (SDQLCHi012-A) derived from a patient with inflammatory bowel disease- 28 carrying compound heterozygote mutations in IL10RA gene","year":2019,"lang":"en","type":"article","venue":"Stem Cell Research","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Natural Science Foundation of China; Health Sciences Centre Foundation; National Science Foundation","keywords":"Biology; Induced pluripotent stem cell; Reprogramming; KLF4; Compound heterozygosity; SOX2; Inflammatory bowel disease; Heterozygote advantage; Peripheral blood mononuclear cell; Karyotype; Cancer research; Molecular biology; Mutation; Gene; Genetics; In vitro; Disease; Chromosome; Pathology; Allele","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005154642,0.0002498996,0.0002832161,0.0003771571,0.000440349,0.00008442131,0.0006603872,0.0001787634,0.0002890761],"category_scores_gemma":[0.00002682916,0.0002147458,0.00007517933,0.0003523128,0.0003683152,0.0002915373,0.0002054345,0.0008797351,0.0004776765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001306761,"about_ca_system_score_gemma":0.0003403042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001027591,"about_ca_topic_score_gemma":0.000227006,"domain_scores_codex":[0.9971992,0.0008397286,0.0004611653,0.000563862,0.0002252726,0.0007107736],"domain_scores_gemma":[0.9982598,0.0003387084,0.0001126023,0.001002521,0.0002474841,0.0000388945],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001120908,0.0006113621,0.01345152,0.00006941517,0.00007750045,0.00007648906,0.009520616,0.002998866,0.9644659,0.0001076788,0.00003766,0.007462159],"study_design_scores_gemma":[0.01736312,0.003256403,0.2770377,0.0009849893,0.0001012397,0.00003940459,0.06429682,0.007303285,0.6206737,0.001094069,0.005833667,0.002015622],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892547,0.008271794,0.0001428277,0.0001212256,0.0002742893,0.0009069653,0.0001196618,0.00006107362,0.0008474324],"genre_scores_gemma":[0.9982991,0.00007882706,0.00005836938,0.00004972411,0.000006378862,0.00007877308,0.0008157641,0.00003887391,0.0005742075],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3437922,"threshold_uncertainty_score":0.8757079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01973076023937128,"score_gpt":0.2676108646275425,"score_spread":0.2478801043881712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}