{"id":"W2973112096","doi":"10.1016/j.scr.2019.101577","title":"An integration-free iPSC line (SDQLCHi012-A) derived from a patient with inflammatory bowel disease- 28 carrying compound heterozygote mutations in IL10RA gene","year":2019,"lang":"en","type":"article","venue":"Stem Cell Research","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Natural Science Foundation of China; Health Sciences Centre Foundation; National Science Foundation","keywords":"Biology; Induced pluripotent stem cell; Reprogramming; KLF4; Compound heterozygosity; SOX2; Inflammatory bowel disease; Heterozygote advantage; Peripheral blood mononuclear cell; Karyotype; Cancer research; Molecular biology; Mutation; Gene; Genetics; In vitro; Disease; Chromosome; Pathology; Allele","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001279008,0.0003510938,0.0003128206,0.0005351823,0.0003026665,0.0002598334,0.0003129802,0.0005979748,0.003336974],"category_scores_gemma":[0.0002698491,0.0001424145,0.0003511651,0.0003973216,0.0002092636,0.0001213852,0.0003074815,0.000845994,0.001202648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001401638,"about_ca_system_score_gemma":0.0002006959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005597486,"about_ca_topic_score_gemma":0.0005364203,"domain_scores_codex":[0.9998726,0.00001026082,0.00002527396,0.0000370268,0.00003293043,0.00002194594],"domain_scores_gemma":[0.9998655,0.00003548075,0.00001216744,0.00002191328,0.00001624012,0.00004873489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003774121,0.0002169895,0.009674031,0.00008420495,0.00002420357,0.02294613,0.0002982727,0.0001457727,0.9546216,0.0005577914,0.0009725333,0.01008119],"study_design_scores_gemma":[0.0003853838,0.002645446,0.09905388,0.00008511444,0.0001989622,0.2553005,0.000551013,0.002763115,0.5867504,0.0006671582,0.05151171,0.00008731996],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839088,0.0006920889,0.006031377,0.0002581345,0.0001466147,0.0002207525,0.003823476,0.0001552989,0.004763376],"genre_scores_gemma":[0.9767177,0.0008783854,0.00643651,0.000201526,0.00006076213,0.0001540635,0.01002142,0.00006350411,0.005466227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003336974,"threshold_uncertainty_score":0.01116323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01973076023937128,"score_gpt":0.2676108646275425,"score_spread":0.2478801043881712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}