{"id":"W2973123134","doi":"10.33594/000000147","title":"Identification of a BACE1 Binding Peptide Candidate for the Prevention of Amyloid Beta in Alzheimer’s Disease","year":2019,"lang":"en","type":"article","venue":"Cellular Physiology and Biochemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Deakin University","keywords":"Peptide; Biopanning; Amyloid precursor protein; P3 peptide; Alpha secretase; Chemistry; Amyloid beta; Biochemistry; Cathepsin D; Phage display; Peptide library; Molecular biology; Cleavage (geology); Alzheimer's disease; Biology; Peptide sequence; Enzyme; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001169213,0.00007651734,0.0001655606,0.00003037915,0.00002943092,0.000002360705,0.00005755863,0.00005384291,0.00002610159],"category_scores_gemma":[0.00001919968,0.000053794,0.00008159939,0.00006864729,0.0001247626,0.00002361798,0.00002987451,0.00005644201,0.000003333855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001015486,"about_ca_system_score_gemma":0.00009271549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009940018,"about_ca_topic_score_gemma":4.870008e-7,"domain_scores_codex":[0.9994059,0.00002259212,0.0001856452,0.0001839729,0.00007774695,0.0001241849],"domain_scores_gemma":[0.9994832,0.0000590136,0.0001127697,0.0002298345,0.00004843004,0.00006671903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006530845,0.0002149113,0.02186865,0.0003986299,0.0008722194,0.000001953565,0.00002071276,0.000002380035,0.9756673,0.00002178243,0.00002106015,0.0002573078],"study_design_scores_gemma":[0.001164473,0.00008773219,0.04894088,0.0000903878,0.0004659519,0.00000109018,0.00008140896,0.0003079292,0.9486259,0.000176148,0.000008723015,0.00004936012],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911449,0.008174677,0.000009679535,0.0000733616,0.00002091406,0.0004861577,0.0000666072,0.000003461485,0.00002026449],"genre_scores_gemma":[0.999231,0.0002144268,0.00001343199,0.00000581763,0.00002377812,0.00004363116,0.0003546923,0.000006200717,0.0001070257],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02707222,"threshold_uncertainty_score":0.2193656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0181186461565401,"score_gpt":0.2928663884995555,"score_spread":0.2747477423430154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}