{"id":"W2973123134","doi":"10.33594/000000147","title":"Identification of a BACE1 Binding Peptide Candidate for the Prevention of Amyloid Beta in Alzheimer’s Disease","year":2019,"lang":"en","type":"article","venue":"Cellular Physiology and Biochemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Deakin University","keywords":"Peptide; Biopanning; Amyloid precursor protein; P3 peptide; Alpha secretase; Chemistry; Amyloid beta; Biochemistry; Cathepsin D; Phage display; Peptide library; Molecular biology; Cleavage (geology); Alzheimer's disease; Biology; Peptide sequence; Enzyme; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002093788,0.0004603241,0.0005914216,0.000417993,0.0001739593,0.0003626827,0.0003503843,0.0005231939,0.002387116],"category_scores_gemma":[0.0001897626,0.0001219354,0.0003562854,0.0002323902,0.0001567478,0.000166776,0.0001629863,0.0005471402,0.0007620933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002178321,"about_ca_system_score_gemma":0.0001718048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001537851,"about_ca_topic_score_gemma":0.0001627418,"domain_scores_codex":[0.9999274,0.000011635,0.000005400645,0.00001436298,0.0000237274,0.00001755743],"domain_scores_gemma":[0.9998964,0.00001158612,0.00002185012,0.000005178083,0.00003489946,0.00003009017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003550256,0.000186407,0.0003538656,0.0001527979,0.00002156221,0.0002501947,0.00001457615,0.0001807996,0.9892057,0.0001055862,0.0001575507,0.009015873],"study_design_scores_gemma":[0.0002210575,0.003288851,0.00497123,0.00004597699,0.0001407335,0.002065536,0.00003227102,0.001287335,0.9772284,0.0001498213,0.0105503,0.00001840161],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9706306,0.01632457,0.008461546,0.0004918946,0.0001457618,0.0002374368,0.000577414,0.0001475902,0.002983123],"genre_scores_gemma":[0.9710509,0.006981388,0.01485521,0.0003382283,0.00008140031,0.000152797,0.002147383,0.00003214964,0.00436052],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002387116,"threshold_uncertainty_score":0.007985651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0181186461565401,"score_gpt":0.2928663884995555,"score_spread":0.2747477423430154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}