{"id":"W2973208504","doi":"10.1002/hbm.24782","title":"Applications of amyloid, tau, and neuroinflammation PET imaging to Alzheimer's disease and mild cognitive impairment","year":2019,"lang":"en","type":"review","venue":"Human Brain Mapping","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":185,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Avid Radiopharmaceuticals; Genentech; National Institutes of Health; Servier; National Institute on Aging; National Institute for Health and Care Research; Wellcome Trust; H. Lundbeck A/S; Alzheimer’s Research UK; Pfizer; Biogen; BioClinica; Eisai; CHDI Foundation; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Medical Research Council; Meso Scale Diagnostics; Medical Research Council Canada; F. Hoffmann-La Roche; Alzheimer's Drug Discovery Foundation; Takeda Pharmaceutical Company; European Commission; AbbVie; Alzheimer's Association; Foundation for the National Institutes of Health; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative","keywords":"Positron emission tomography; Neuroinflammation; Disease; Neuroimaging; Biomarker; Neuroscience; Medicine; Pet imaging; Molecular imaging; Amyloid beta; Amyloid (mycology); Alzheimer's disease; Cognitive impairment; Prodromal Stage; Psychology; Pathology; In vivo; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002197797,0.0003837454,0.0009714683,0.000490315,0.0002067622,0.00005850854,0.00009179958,0.00004522999,0.0000481965],"category_scores_gemma":[0.00005497214,0.000340592,0.0002086372,0.0002556118,0.0001413297,0.00009582051,0.0001948191,0.0002135919,0.00006190262],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006108168,"about_ca_system_score_gemma":0.0002633568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002074585,"about_ca_topic_score_gemma":0.000001641981,"domain_scores_codex":[0.9980379,0.000143234,0.0004991994,0.000622416,0.0003497261,0.0003475113],"domain_scores_gemma":[0.9983066,0.0002701483,0.0002616055,0.0003824684,0.0001309007,0.000648224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001936683,0.000723351,0.004015023,0.05550835,0.01534948,0.0004452482,0.0005765937,4.070679e-7,0.00002193483,0.0006849131,0.002009918,0.9204711],"study_design_scores_gemma":[0.01277462,0.001333949,0.194632,0.1517597,0.06643226,0.0006459397,0.001412447,0.0002730523,0.000006780216,0.001284865,0.5661931,0.003251286],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00112966,0.991872,0.00009122291,0.0002634677,0.00001521481,0.006055111,0.0002457327,0.00004422059,0.0002833428],"genre_scores_gemma":[0.01649698,0.9795403,0.0001988289,0.000230219,0.000222802,0.001474889,0.001601725,0.000114387,0.0001198128],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9172198,"threshold_uncertainty_score":0.9999046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06488596967303645,"score_gpt":0.3715055622344027,"score_spread":0.3066195925613663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}