{"id":"W2973208504","doi":"10.1002/hbm.24782","title":"Applications of amyloid, tau, and neuroinflammation PET imaging to Alzheimer's disease and mild cognitive impairment","year":2019,"lang":"en","type":"review","venue":"Human Brain Mapping","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":185,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Avid Radiopharmaceuticals; Genentech; National Institutes of Health; Servier; National Institute on Aging; National Institute for Health and Care Research; Wellcome Trust; H. Lundbeck A/S; Alzheimer’s Research UK; Pfizer; Biogen; BioClinica; Eisai; CHDI Foundation; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Medical Research Council; Meso Scale Diagnostics; Medical Research Council Canada; F. Hoffmann-La Roche; Alzheimer's Drug Discovery Foundation; Takeda Pharmaceutical Company; European Commission; AbbVie; Alzheimer's Association; Foundation for the National Institutes of Health; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative","keywords":"Positron emission tomography; Neuroinflammation; Disease; Neuroimaging; Biomarker; Neuroscience; Medicine; Pet imaging; Molecular imaging; Amyloid beta; Amyloid (mycology); Alzheimer's disease; Cognitive impairment; Prodromal Stage; Psychology; Pathology; In vivo; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005908923,0.001003408,0.001745539,0.004345413,0.0002829214,0.0008743043,0.0007201105,0.001069098,0.002907213],"category_scores_gemma":[0.0008104499,0.0003477843,0.0008312925,0.003196191,0.0005405595,0.001088555,0.0006996545,0.001524341,0.001297627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000700807,"about_ca_system_score_gemma":0.001089053,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001523998,"about_ca_topic_score_gemma":0.002407439,"domain_scores_codex":[0.9997805,0.00004212065,0.00003909062,0.00003857497,0.00008031078,0.00001944422],"domain_scores_gemma":[0.9997104,0.0001464042,0.00004124339,0.000008903889,0.00007452839,0.00001856696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001113357,0.00008405036,0.0002666676,0.04034977,0.0001980687,0.00033267,0.000111544,0.0003964569,0.002818354,0.003544,0.01871714,0.93307],"study_design_scores_gemma":[0.00003358646,0.0001548252,0.00261503,0.0110083,0.0003609501,0.002941257,0.0001051894,0.0001726213,0.000965016,0.00349178,0.9781153,0.00003617346],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009619347,0.9989832,0.00006647621,0.0000978143,0.0001018904,0.000004261422,0.00001081014,0.000003980539,0.0006352788],"genre_scores_gemma":[0.0005069947,0.9989257,0.0001086785,0.0001064459,0.00006754132,0.000006497229,0.00001539537,8.567035e-7,0.000261785],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004345413,"threshold_uncertainty_score":0.00972563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06488596967303645,"score_gpt":0.3715055622344027,"score_spread":0.3066195925613663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}