{"id":"W2973215412","doi":"10.5830/cvja-2019-039","title":"Long-term safety and efficacy of alirocumab in South African patients with heterozygous familial hypercholesterolaemia: the ODYSSEY Open-Label Extension study","year":2019,"lang":"en","type":"article","venue":"Cardiovascular journal of South Africa/Cardiovascular journal of Southern Africa","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nexus Clinical Research (Canada)","funders":"","keywords":"Alirocumab; Discontinuation; Medicine; PCSK9; Placebo; Internal medicine; Ldl cholesterol; Familial hypercholesterolemia; Open label; Gastroenterology; Clinical trial; Lipoprotein; Cholesterol; LDL receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001615563,0.000615376,0.001053905,0.0001999448,0.0003606026,0.0004633574,0.0002355974,0.00056904,0.00186009],"category_scores_gemma":[0.001708701,0.0002825185,0.0007042197,0.0002338338,0.0004425926,0.0004099688,0.0002720405,0.0009265177,0.0002840482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004350052,"about_ca_system_score_gemma":0.0008197543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001014261,"about_ca_topic_score_gemma":0.001545066,"domain_scores_codex":[0.9996213,0.0002081804,0.00003205449,0.00004272365,0.00004035758,0.00005538075],"domain_scores_gemma":[0.9989282,0.000217996,0.0003680835,0.0000838142,0.00009973974,0.0003020771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.7633737,0.02087103,0.0854926,0.001590864,0.002256593,0.0009217255,0.001421766,0.0005521336,0.02406008,0.0001438828,0.001304705,0.09801105],"study_design_scores_gemma":[0.4136092,0.2403423,0.334401,0.0002030927,0.002358194,0.001171507,0.0004392447,0.001099995,0.00257612,0.0001455986,0.003579934,0.00007388654],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988407,0.0006799163,0.00004981528,0.00006178069,0.000008967011,0.0001149197,0.00007395387,0.000004279686,0.0001657439],"genre_scores_gemma":[0.9985261,0.0005704955,0.0002106078,0.0001332406,0.00002824953,0.0001702742,0.0001231693,0.000002016779,0.0002359656],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00186009,"threshold_uncertainty_score":0.008544028,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.021152942291312,"score_gpt":0.2396580567549213,"score_spread":0.2185051144636093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}