{"id":"W2973225303","doi":"10.1139/cjpp-2019-0024","title":"Human concentrations of uric acid scavenges adaptive and maladaptive reactive oxygen species in isolated rat hearts subjected to ischemic stress","year":2019,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Cardiac Ischemia and Reperfusion","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Uric acid; Reactive oxygen species; Oxidative stress; Chemistry; Mitochondrial permeability transition pore; Biochemistry; Pharmacology; Mitochondrial ROS; Antioxidant; Mitochondrion; Cardioprotection; Ischemia; Allopurinol; Internal medicine; Medicine; Apoptosis; Programmed cell death","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006233622,0.0003974764,0.0005542921,0.0003381897,0.0001979861,0.0003863754,0.0002802155,0.0004869414,0.002278452],"category_scores_gemma":[0.0005231742,0.0002149259,0.0002112469,0.0002895231,0.0004600341,0.0003101462,0.000204171,0.0006589922,0.0002524511],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002669501,"about_ca_system_score_gemma":0.0004797388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001029407,"about_ca_topic_score_gemma":0.001486378,"domain_scores_codex":[0.9997615,0.00006309951,0.00002161738,0.00003970478,0.0000503219,0.0000638335],"domain_scores_gemma":[0.9998077,0.0000327886,0.00004169387,0.00003609781,0.00002283148,0.00005889601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009738665,0.000671228,0.0006772381,0.0001400058,0.00007122737,0.0001296052,0.0001438086,0.0001599489,0.9794485,0.0002365752,0.0002104326,0.008372834],"study_design_scores_gemma":[0.0004509253,0.009925133,0.005276207,0.0000257482,0.0001547721,0.0002159795,0.00007928797,0.001094154,0.9804682,0.0001760576,0.00211955,0.00001406122],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876223,0.007943608,0.002774403,0.000212913,0.0001187428,0.00006458953,0.0001651362,0.00008439591,0.001013768],"genre_scores_gemma":[0.9935005,0.00234364,0.001773363,0.0001095696,0.00006915994,0.00005788287,0.0003297999,0.00001783202,0.001798217],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002278452,"threshold_uncertainty_score":0.007622182,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01195534875937094,"score_gpt":0.2597578675241102,"score_spread":0.2478025187647393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}