{"id":"W2973263350","doi":"10.1242/dmm.039669","title":"Medroxyprogesterone acetate alters the vaginal microbiota and microenvironment in women and increases susceptibility to HIV-1 in humanized mice","year":2019,"lang":"en","type":"article","venue":"Disease Models & Mechanisms","topic":"Reproductive tract infections research","field":"Immunology and Microbiology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; Toronto Public Health; University of Toronto; University Health Network; Université Laval; Mount Sinai Hospital; University of Manitoba; McMaster University","funders":"Ontario Ministry of Health and Long-Term Care; Canadian Institutes of Health Research; Ontario HIV Treatment Network; Government of Ontario","keywords":"Medroxyprogesterone acetate; Humanized mouse; Human immunodeficiency virus (HIV); Medroxyprogesterone; Medicine; Immunology; Biology; Internal medicine; Estrogen; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008253388,0.0002414376,0.00031431,0.000223807,0.000112224,0.00004227365,0.0002214239,0.00008350905,0.0002175784],"category_scores_gemma":[0.00004669585,0.0001967894,0.00003429082,0.0001644233,0.0002101433,0.0002017283,0.0003475547,0.0003207762,0.0001690567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002389995,"about_ca_system_score_gemma":0.00005777808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003314923,"about_ca_topic_score_gemma":0.0001104916,"domain_scores_codex":[0.997777,0.000488619,0.0002883168,0.0008100219,0.00007015808,0.0005658402],"domain_scores_gemma":[0.9991383,0.0001114112,0.00005329646,0.0005588752,0.00002863767,0.0001094639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001361778,0.0005400941,0.01119016,0.00006679365,0.00006157174,0.00001223182,0.002097795,0.0003587923,0.9824011,0.000686556,0.00003234966,0.001190808],"study_design_scores_gemma":[0.01372294,0.001132661,0.8460255,0.000307188,0.0001121453,0.0001447005,0.004316951,0.001045947,0.1001498,0.03056544,0.00101561,0.001461128],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957408,0.001228545,0.0003870947,0.000944883,0.00007545634,0.001493919,0.00008182991,0.00002360397,0.00002391065],"genre_scores_gemma":[0.9987006,0.0001437365,0.0001496186,0.0003092125,0.000006539351,0.0002447592,0.0000374128,0.00002419578,0.0003839208],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8822513,"threshold_uncertainty_score":0.802484,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01171097453457476,"score_gpt":0.2435650533705612,"score_spread":0.2318540788359865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}