{"id":"W2973294764","doi":"10.1038/s41467-019-12199-1","title":"Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Research Council Canada; Western Economic Diversification Canada; Canadian Institutes of Health Research; Office of Science; Michigan Technology Tri-Corridor; Astellas Pharma; University of Saskatchewan; Ministry of Trade, Industry and Energy; Natural Sciences and Engineering Research Council of Canada; Canadian Light Source; Amplyx; Astellas Pharma Global Development; National Institutes of Health; Michigan Economic Development Corporation; U.S. Department of Health and Human Services; Argonne National Laboratory; U.S. Department of Energy","keywords":"Calcineurin; Cryptococcus neoformans; Aspergillus fumigatus; FKBP; Candida albicans; Cryptococcosis; Biology; Coccidioides immitis; Microbiology; Virulence; Fungal protein; Echinocandins; Antifungal drug; Cryptococcus; Peptidylprolyl isomerase; Antifungal; Biochemistry; Fluconazole; Saccharomyces cerevisiae; Yeast; Medicine; Transplantation; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001329627,0.0002308706,0.000185158,0.00006527358,0.000244684,0.00007075298,0.001373938,0.0003963192,0.00009419324],"category_scores_gemma":[0.0008740507,0.00023543,0.00009192701,0.0003181323,0.00007961681,0.00000931967,0.001067203,0.0005450997,0.00007385448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003865315,"about_ca_system_score_gemma":0.0003202705,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000284105,"about_ca_topic_score_gemma":0.0002375109,"domain_scores_codex":[0.9985702,0.0002067144,0.0002611787,0.0004623236,0.0002220198,0.0002775737],"domain_scores_gemma":[0.9969391,0.0001188884,0.0001156743,0.002271117,0.0003716436,0.0001835594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005549977,0.00007703172,0.07882793,0.00001097804,0.00008782198,0.000006529548,0.0001821222,0.0001065895,0.9104312,0.0002917106,0.009503206,0.0004194028],"study_design_scores_gemma":[0.001056804,0.0001216731,0.3375291,0.0001040349,0.0001055428,0.00002871372,0.0003226873,0.0000955724,0.5620402,0.0002554081,0.09752142,0.0008188732],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935193,0.003319529,0.000166408,0.0005163387,0.0004701283,0.0003783653,0.0006015022,0.00004338141,0.0009850159],"genre_scores_gemma":[0.9866111,0.00006701161,0.009402545,0.001742419,0.00018399,0.00003310832,0.001729576,0.00004647373,0.000183759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.348391,"threshold_uncertainty_score":0.9600558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02187046846773747,"score_gpt":0.298897820951989,"score_spread":0.2770273524842515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}