{"id":"W2973294764","doi":"10.1038/s41467-019-12199-1","title":"Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Research Council Canada; Western Economic Diversification Canada; Canadian Institutes of Health Research; Office of Science; Michigan Technology Tri-Corridor; Astellas Pharma; University of Saskatchewan; Ministry of Trade, Industry and Energy; Natural Sciences and Engineering Research Council of Canada; Canadian Light Source; Amplyx; Astellas Pharma Global Development; National Institutes of Health; Michigan Economic Development Corporation; U.S. Department of Health and Human Services; Argonne National Laboratory; U.S. Department of Energy","keywords":"Calcineurin; Cryptococcus neoformans; Aspergillus fumigatus; FKBP; Candida albicans; Cryptococcosis; Biology; Coccidioides immitis; Microbiology; Virulence; Fungal protein; Echinocandins; Antifungal drug; Cryptococcus; Peptidylprolyl isomerase; Antifungal; Biochemistry; Fluconazole; Saccharomyces cerevisiae; Yeast; Medicine; Transplantation; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001724094,0.0003046092,0.0003615178,0.0001874484,0.0005510981,0.0004819636,0.0005689142,0.0003808747,0.002103083],"category_scores_gemma":[0.0003778097,0.0002205359,0.0001958608,0.0003286657,0.0001775818,0.0003783507,0.0003396806,0.001121489,0.0002619979],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008187906,"about_ca_system_score_gemma":0.0007705006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008859075,"about_ca_topic_score_gemma":0.0129609,"domain_scores_codex":[0.9999148,0.00001125767,0.000003936883,0.00001151215,0.00004105916,0.00001755081],"domain_scores_gemma":[0.9998744,0.00003954422,0.00001794923,0.000007752361,0.00003650218,0.00002391774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001140035,0.0006550796,0.007357125,0.000828601,0.0001812547,0.001417446,0.0009414103,0.02864034,0.9071839,0.007436487,0.01155303,0.03266525],"study_design_scores_gemma":[0.001241301,0.0007215975,0.0291731,0.0001609157,0.0002287924,0.001329141,0.001333466,0.3767664,0.5258588,0.00441277,0.05865951,0.0001143324],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9789972,0.001507884,0.01135191,0.0008478204,0.0001105214,0.00006243415,0.001409612,0.0004844079,0.0052282],"genre_scores_gemma":[0.9679987,0.001956302,0.02303469,0.0001694014,0.00002104128,0.00009416692,0.004506987,0.000136709,0.002082027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008859075,"threshold_uncertainty_score":0.01761502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02187046846773747,"score_gpt":0.298897820951989,"score_spread":0.2770273524842515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}