{"id":"W2973437633","doi":"10.1016/s0140-6736(19)31881-1","title":"Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials","year":2019,"lang":"en","type":"article","venue":"The Lancet","topic":"Sinusitis and nasal conditions","field":"Medicine","cited_by":1479,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Medicine; Dupilumab; Nasal polyps; Placebo; Internal medicine; Placebo-controlled study; Sinusitis; Clinical endpoint; Randomized controlled trial; Asthma; Chronic rhinosinusitis; Surgery; Double blind; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002496452,0.001075974,0.002812815,0.0002767332,0.000415766,0.001063367,0.0006174422,0.001814073,0.002271847],"category_scores_gemma":[0.002271211,0.0005450306,0.002742071,0.0003288393,0.001066199,0.0009480141,0.0003209702,0.002484414,0.0004146775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006994078,"about_ca_system_score_gemma":0.0007109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001022224,"about_ca_topic_score_gemma":0.002970729,"domain_scores_codex":[0.99933,0.000313825,0.00006237184,0.0001122247,0.00006729869,0.000114203],"domain_scores_gemma":[0.9989315,0.0003996628,0.0002962175,0.00005265012,0.00006641256,0.000253501],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8966644,0.002367119,0.003821446,0.003903594,0.003143001,0.0001678484,0.000224544,0.0004872643,0.006570868,0.000163136,0.001979655,0.08050708],"study_design_scores_gemma":[0.9130741,0.06889975,0.01325247,0.0001582964,0.001546444,0.0002797936,0.00007905214,0.0003718163,0.000635776,0.0001786268,0.001480166,0.00004372795],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9606584,0.03467473,0.0003239418,0.000880545,0.0004743778,0.0006930076,0.0006461723,0.0000670331,0.001581913],"genre_scores_gemma":[0.9879856,0.007489118,0.0007965619,0.00125929,0.0003763487,0.0005576171,0.0006740119,0.00001206008,0.0008495003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002812815,"threshold_uncertainty_score":0.01320267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02457170509005804,"score_gpt":0.2874956789518754,"score_spread":0.2629239738618174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}