{"id":"W2973507295","doi":"10.1038/s41467-019-11811-8","title":"VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Digestive system and related health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":101,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Calgary; Cumming School of Medicine, University of Calgary; Government of Canada; Crohn's and Colitis Canada","keywords":"Mucin; Exocytosis; Cell biology; Homeostasis; Mucin 2; Goblet cell; Innate immune system; Biology; Chemistry; Immunology; Secretion; Epithelium; Immune system; Biochemistry; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002903471,0.0002142007,0.000244898,0.00009505157,0.0002070858,0.00003498115,0.001073322,0.0006999719,0.0000784447],"category_scores_gemma":[0.0001832776,0.0001981972,0.0001123018,0.0003272781,0.0001409576,0.000007707571,0.0005112157,0.0009357962,0.000420739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008145229,"about_ca_system_score_gemma":0.0002586049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002171314,"about_ca_topic_score_gemma":0.0006922029,"domain_scores_codex":[0.9984716,0.000317044,0.0003424315,0.0003843145,0.0001589702,0.0003257018],"domain_scores_gemma":[0.9972687,0.0002059107,0.0001995613,0.001924599,0.0002552764,0.0001459109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002390637,0.0009094906,0.05869098,0.000099654,0.000662655,0.000009240757,0.0006993015,0.0001015318,0.884521,0.005634218,0.04610126,0.002331602],"study_design_scores_gemma":[0.002738378,0.0007806079,0.06598265,0.000330062,0.0001523641,0.00003034296,0.0008917043,0.0006210044,0.07843763,0.0003188104,0.8487005,0.001015916],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9694111,0.01622479,0.00009856982,0.003441122,0.0005478413,0.0007250594,0.0004819326,0.00008048723,0.008989064],"genre_scores_gemma":[0.9901024,0.003552001,0.002066385,0.001101701,0.00007473348,0.00004699589,0.002345116,0.00003852448,0.00067219],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8060834,"threshold_uncertainty_score":0.8082249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0107115207227462,"score_gpt":0.2752835029065984,"score_spread":0.2645719821838521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}