{"id":"W2973507295","doi":"10.1038/s41467-019-11811-8","title":"VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Digestive system and related health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":101,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Calgary; Cumming School of Medicine, University of Calgary; Government of Canada; Crohn's and Colitis Canada","keywords":"Mucin; Exocytosis; Cell biology; Homeostasis; Mucin 2; Goblet cell; Innate immune system; Biology; Chemistry; Immunology; Secretion; Epithelium; Immune system; Biochemistry; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009022428,0.0002896691,0.0002405105,0.0001978964,0.0001920196,0.0004530399,0.0002629749,0.0004134678,0.001382808],"category_scores_gemma":[0.0001101206,0.0001182471,0.0002060396,0.00008182797,0.0002664512,0.000350993,0.0004182437,0.0007265311,0.0006203232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002580111,"about_ca_system_score_gemma":0.0001156212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002329388,"about_ca_topic_score_gemma":0.0002052649,"domain_scores_codex":[0.9998581,0.00001731534,0.000009986852,0.00003453127,0.00003707036,0.0000429479],"domain_scores_gemma":[0.9998727,0.000008244513,0.00002860675,0.00002191141,0.00001608399,0.00005243543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007979276,0.000005183726,0.0002114625,0.00001804516,0.000001580019,0.00005618905,0.000005118626,0.00003294608,0.9988337,0.00007679466,0.00003658555,0.0006427225],"study_design_scores_gemma":[0.00002005125,0.0002650062,0.01140873,0.00001593308,0.000006775921,0.0006113746,0.00007203544,0.001303092,0.9829661,0.0002022109,0.003120267,0.000008455028],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932129,0.001322046,0.003269272,0.0002023451,0.00003885792,0.00001307848,0.0004420406,0.0002228784,0.001276617],"genre_scores_gemma":[0.9954302,0.0002842263,0.001308408,0.00005000079,0.00001253971,0.00001653559,0.0003367919,0.00003267999,0.002528675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001382808,"threshold_uncertainty_score":0.004625916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0107115207227462,"score_gpt":0.2752835029065984,"score_spread":0.2645719821838521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}