{"id":"W2973514824","doi":"10.1016/s1470-2045(19)30569-8","title":"Intensity-modulated fractionated radiotherapy versus stereotactic body radiotherapy for prostate cancer (PACE-B): acute toxicity findings from an international, randomised, open-label, phase 3, non-inferiority trial","year":2019,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Prostate Cancer Diagnosis and Treatment","field":"Medicine","cited_by":536,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Health Sciences Centre; Sunnybrook Health Science Centre","funders":"National Institute for Health and Care Research; Institute of Cancer Research; Metropolitan Museum of Art; Cancer Research UK; Manchester Biomedical Research Centre; Accuray; Cilag; NIHR Bristol Biomedical Research Centre; National Health Insurance Service; Royal Marsden NHS Foundation Trust","keywords":"Medicine; Radiation therapy; Prostate cancer; Dose fractionation; Clinical endpoint; Androgen deprivation therapy; Prostate; Internal medicine; Randomized controlled trial; Oncology; Urology; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007178109,0.0003455223,0.001373903,0.00009355986,0.0002032305,0.0001250729,0.0004977347,0.0002202594,0.000707736],"category_scores_gemma":[0.00007370803,0.000242223,0.0001301176,0.0001762326,0.0001349774,0.0003984343,0.00007497474,0.0003889795,0.00001488928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001604366,"about_ca_system_score_gemma":0.0005187212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001284175,"about_ca_topic_score_gemma":0.0001528093,"domain_scores_codex":[0.9979107,0.0002232209,0.0004856422,0.0006507129,0.0002430993,0.0004866121],"domain_scores_gemma":[0.9978706,0.0007437144,0.0003717115,0.0005936239,0.0002680555,0.0001522556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9279099,0.003207557,0.006815318,0.00002275305,0.005467764,0.00005097092,0.0009416619,0.00002584528,0.04238351,0.00005037408,0.005339065,0.007785318],"study_design_scores_gemma":[0.8816173,0.02139883,0.005356944,0.00008425838,0.0006924128,0.00002296235,0.00006031797,0.007170938,0.005653219,0.0001262015,0.07750951,0.0003071021],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9669291,0.0004956252,0.0001345765,0.01843805,0.00437854,0.008619555,0.0006025026,0.00008900937,0.0003130324],"genre_scores_gemma":[0.9743706,0.01081194,0.001824494,0.007351899,0.001938432,0.002346346,0.000808018,0.00008573304,0.0004625276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07217045,"threshold_uncertainty_score":0.9877569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06750216261748353,"score_gpt":0.4349405895770075,"score_spread":0.367438426959524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}