{"id":"W2973607368","doi":"10.3390/cells8101120","title":"Protective Effect of Probiotic Bacteria and Estrogen in Preventing HIV-1-Mediated Impairment of Epithelial Barrier Integrity in Female Genital Tract","year":2019,"lang":"en","type":"article","venue":"Cells","topic":"Reproductive tract infections research","field":"Immunology and Microbiology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Lawson Health Research Institute; McMaster University","funders":"National Institutes of Health; Canadian Institutes of Health Research; Ontario HIV Treatment Network; Danone","keywords":"Proinflammatory cytokine; Lactobacillus rhamnosus; Estrogen; Probiotic; Hormone; Medroxyprogesterone acetate; Barrier function; Bacterial vaginosis; Biology; Lactobacillus; Dysbiosis; Immune system; Immunology; Gut flora; Microbiology; Inflammation; Endocrinology; Bacteria; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001080005,0.0001371229,0.0003824683,0.0002492457,0.00001848043,0.00000481365,0.0001018088,0.0001827636,0.0002818317],"category_scores_gemma":[0.0002530638,0.0001135606,0.00006516239,0.0002126166,0.0001760765,0.0001027153,0.00007803941,0.0005222706,0.0001087041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008180624,"about_ca_system_score_gemma":0.00008760452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002496388,"about_ca_topic_score_gemma":0.00001480092,"domain_scores_codex":[0.9983774,0.0006572491,0.0003485731,0.0003150819,0.00003821124,0.0002634381],"domain_scores_gemma":[0.9992529,0.0003196756,0.0001317862,0.0002213003,0.00005824137,0.00001605201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003275923,0.0002994087,0.2823009,0.0001915691,0.00004067323,0.000001925076,0.0005855995,0.000009477245,0.7156415,0.000002639739,0.000001183732,0.0005975608],"study_design_scores_gemma":[0.001389393,0.0008591958,0.2712143,0.00007865552,0.00000867878,0.00001371887,0.0001103305,0.000007147542,0.7262199,0.00001137468,0.00001836966,0.00006892324],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973826,0.0001899825,0.000005565286,0.000008433678,0.0001544806,0.002083885,0.00005720793,0.000008966273,0.0001088406],"genre_scores_gemma":[0.9996576,0.000007746007,0.00003805144,7.396666e-7,0.000007991553,0.00006337569,0.00002090586,0.00001149374,0.0001921157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01108652,"threshold_uncertainty_score":0.4630867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007715630970103282,"score_gpt":0.2539987788737345,"score_spread":0.2462831479036312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}