{"id":"W2973607368","doi":"10.3390/cells8101120","title":"Protective Effect of Probiotic Bacteria and Estrogen in Preventing HIV-1-Mediated Impairment of Epithelial Barrier Integrity in Female Genital Tract","year":2019,"lang":"en","type":"article","venue":"Cells","topic":"Reproductive tract infections research","field":"Immunology and Microbiology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Lawson Health Research Institute; McMaster University","funders":"National Institutes of Health; Canadian Institutes of Health Research; Ontario HIV Treatment Network; Danone","keywords":"Proinflammatory cytokine; Lactobacillus rhamnosus; Estrogen; Probiotic; Hormone; Medroxyprogesterone acetate; Barrier function; Bacterial vaginosis; Biology; Lactobacillus; Dysbiosis; Immune system; Immunology; Gut flora; Microbiology; Inflammation; Endocrinology; Bacteria; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001657441,0.0002130516,0.0003978158,0.000177887,0.0001250447,0.0002010573,0.0001543597,0.0002573325,0.001330376],"category_scores_gemma":[0.0001863018,0.00009364083,0.0002126548,0.0001196506,0.0001647392,0.0001556596,0.0002222296,0.0003529159,0.0001309908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008025154,"about_ca_system_score_gemma":0.0003113927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004480522,"about_ca_topic_score_gemma":0.000974326,"domain_scores_codex":[0.9998902,0.00003745541,0.000008230061,0.00001307688,0.00001872688,0.00003227116],"domain_scores_gemma":[0.9999344,0.00001279742,0.00001166238,0.000005899513,0.000008521736,0.00002670388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005336242,0.0007399797,0.001392039,0.0003357391,0.00005294884,0.0001349612,0.00005450228,0.0001651282,0.9612665,0.00009013724,0.0001258579,0.03030603],"study_design_scores_gemma":[0.0005969568,0.05138368,0.05367893,0.0001609828,0.0003254198,0.0007085894,0.0003963486,0.001200756,0.8788143,0.0002148176,0.01249369,0.00002556856],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869106,0.01175203,0.0002837442,0.0001678471,0.00005421895,0.00002744239,0.00007401832,0.00001668852,0.000713392],"genre_scores_gemma":[0.9929687,0.004799183,0.0009156244,0.0001051955,0.00004389089,0.00002816197,0.00009830863,0.000004718634,0.001036058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001330376,"threshold_uncertainty_score":0.00445056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007715630970103282,"score_gpt":0.2539987788737345,"score_spread":0.2462831479036312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}