{"id":"W2973607898","doi":"10.1182/blood.2019002600","title":"The double-hit signature identifies double-hit diffuse large B-cell lymphoma with genetic events cryptic to FISH","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of British Columbia; Simon Fraser University","funders":"Canadian Institutes of Health Research; BC Cancer Foundation; Mitacs; Terry Fox Research Institute; Michael Smith Health Research BC","keywords":"BCL6; Biology; Diffuse large B-cell lymphoma; Germinal center; Fluorescence in situ hybridization; Cancer research; Lymphoma; Chromosomal translocation; Gene expression profiling; Copy-number variation; Genetics; Gene; B cell; Gene expression; Genome; Chromosome; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002328344,0.0002859868,0.0002164619,0.0008533974,0.0001181006,0.0003135531,0.0001562177,0.0003409796,0.001865944],"category_scores_gemma":[0.0002941901,0.0001579555,0.000130041,0.0002744581,0.0003356925,0.0002336708,0.0004054408,0.0002028028,0.0003697678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002107695,"about_ca_system_score_gemma":0.00008192315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000508445,"about_ca_topic_score_gemma":0.001396165,"domain_scores_codex":[0.999818,0.00002264348,0.0000159978,0.00005362296,0.00004401848,0.0000457222],"domain_scores_gemma":[0.9998282,0.0000419574,0.00004814772,0.00003059396,0.00001804959,0.0000329982],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000212237,0.00001057544,0.02859438,0.00005319235,0.00002051734,0.001015749,0.00005550236,0.0001176793,0.9635971,0.0001134479,0.00005141355,0.006158105],"study_design_scores_gemma":[0.00004378896,0.0004973478,0.317674,0.00001632186,0.00008653008,0.03238522,0.000366633,0.004917146,0.6395913,0.0006253695,0.003775721,0.00002056607],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925042,0.0003251733,0.005636429,0.00003191344,0.000003166039,0.00002776487,0.0001818873,0.0001253605,0.001164064],"genre_scores_gemma":[0.9961738,0.0001331219,0.003058025,0.00002659103,0.000001678594,0.00001390599,0.0002366234,0.00001820101,0.0003380441],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001865944,"threshold_uncertainty_score":0.006242216,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00696804429419057,"score_gpt":0.2240820150676943,"score_spread":0.2171139707735038,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}