{"id":"W2973607898","doi":"10.1182/blood.2019002600","title":"The double-hit signature identifies double-hit diffuse large B-cell lymphoma with genetic events cryptic to FISH","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of British Columbia; Simon Fraser University","funders":"Canadian Institutes of Health Research; BC Cancer Foundation; Mitacs; Terry Fox Research Institute; Michael Smith Health Research BC","keywords":"BCL6; Biology; Diffuse large B-cell lymphoma; Germinal center; Fluorescence in situ hybridization; Cancer research; Lymphoma; Chromosomal translocation; Gene expression profiling; Copy-number variation; Genetics; Gene; B cell; Gene expression; Genome; Chromosome; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000122793,0.0003578236,0.0004151142,0.00008891703,0.0002372563,0.0001308352,0.0002832686,0.0001543246,0.0001510293],"category_scores_gemma":[0.00000971797,0.0002118934,0.0001688282,0.0002906368,0.00003488792,0.00008166484,0.0001364547,0.0001076732,0.0009776338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001167812,"about_ca_system_score_gemma":0.0001620906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009370221,"about_ca_topic_score_gemma":0.0001704254,"domain_scores_codex":[0.99783,0.00003495469,0.0003150016,0.0005500917,0.0006275483,0.00064237],"domain_scores_gemma":[0.9984365,0.0001091427,0.0001227266,0.0009025658,0.0001308356,0.0002982582],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005876219,0.05911493,0.8982134,0.0005876966,0.002944051,0.001555809,0.002576109,0.00003513995,0.005354634,0.0009432956,0.01779028,0.005008456],"study_design_scores_gemma":[0.2570032,0.002153204,0.6584786,0.0005510041,0.001935253,0.0002362338,0.0004993936,0.00002518482,0.04765945,0.00009252772,0.03063159,0.0007343814],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918635,0.001415816,0.000006457773,0.001355301,0.0003074627,0.001684644,0.00002813314,0.00009264074,0.003246006],"genre_scores_gemma":[0.9873267,0.0001811875,0.0001710167,0.0009278504,0.0001752034,0.0002975088,0.00004228685,0.00006425157,0.01081393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2511269,"threshold_uncertainty_score":0.9998002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00696804429419057,"score_gpt":0.2240820150676943,"score_spread":0.2171139707735038,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}