{"id":"W2973735358","doi":"10.1002/jbm4.10237","title":"In Vivo Bone Effects of a Novel Bisphosphonate‐EP4a Conjugate Drug (C3) for Reversing Osteoporotic Bone Loss in an Ovariectomized Rat Model","year":2019,"lang":"en","type":"article","venue":"JBMR Plus","topic":"Bone health and treatments","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Simon Fraser University; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Dalhousie University","funders":"Institute of Musculoskeletal Health and Arthritis; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Crohn's and Colitis Canada; Health Research","keywords":"Ovariectomized rat; Reversing; In vivo; Bisphosphonate; Osteoporosis; Medicine; Drug; Pharmacology; Conjugate; Internal medicine; Endocrinology; Estrogen; Materials science; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001852058,0.0004659658,0.0003478976,0.0004537491,0.0001559757,0.000158889,0.0002148324,0.000502236,0.001043441],"category_scores_gemma":[0.00008139558,0.0001559247,0.000380761,0.0002074404,0.0002264123,0.0001934285,0.0001031376,0.0006670303,0.0001871975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001819787,"about_ca_system_score_gemma":0.0003196884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001022618,"about_ca_topic_score_gemma":0.001508842,"domain_scores_codex":[0.9999037,0.00001250898,0.000006721275,0.00001611279,0.00003361609,0.00002745429],"domain_scores_gemma":[0.9999194,0.000008763291,0.00002027551,0.00000734252,0.00001365363,0.00003053219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001336056,0.0009205124,0.0001367739,0.00006155735,0.00001516802,0.00004255913,0.00001192926,0.0001409936,0.9938811,0.00006348565,0.00005958002,0.003330281],"study_design_scores_gemma":[0.0002721841,0.01393299,0.002177675,0.000007388753,0.00005866314,0.0001152458,0.00002256618,0.001056429,0.9809522,0.00003558307,0.001359657,0.00000935067],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965681,0.001047766,0.001392022,0.00006662522,0.00004101945,0.00007623468,0.0002384854,0.00005048304,0.0005193305],"genre_scores_gemma":[0.9926831,0.001155636,0.002493857,0.00006974539,0.00001888372,0.0001352444,0.0003843441,0.00001214074,0.003047003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001043441,"threshold_uncertainty_score":0.003490627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01390363233599916,"score_gpt":0.290155625653386,"score_spread":0.2762519933173869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}