{"id":"W2973785281","doi":"10.1038/s42003-019-0588-y","title":"Neutrophils homing into the retina trigger pathology in early age-related macular degeneration","year":2019,"lang":"en","type":"article","venue":"Communications Biology","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Ontario Institute for Cancer Research","funders":"Research to Prevent Blindness; National Eye Institute; F. Hoffmann-La Roche; Roche; International Retinal Research Foundation; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Infiltration (HVAC); Inflammation; Macular degeneration; Retina; Downregulation and upregulation; Phenotype; Pathology; Homing (biology); Biology; Cell biology; Immunology; Medicine; Neuroscience; Ophthalmology; Materials science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001762274,0.0000960153,0.0002001658,0.00009287256,0.0001121689,0.000009700208,0.0002987675,0.0001258176,0.00005121435],"category_scores_gemma":[0.00006219817,0.00006403547,0.00007627465,0.0002115468,0.0002128323,0.00002940321,0.0001566826,0.0002194761,0.0002105385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000599248,"about_ca_system_score_gemma":0.00004054244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001653535,"about_ca_topic_score_gemma":0.00005106611,"domain_scores_codex":[0.9989936,0.0003831985,0.0002573441,0.0001759335,0.00003845081,0.0001515072],"domain_scores_gemma":[0.9983934,0.00013575,0.00007970794,0.001300307,0.00005149615,0.00003934644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002010908,0.0004695083,0.9028926,0.00002003432,0.0001270488,0.00006570019,0.001848505,0.00001614392,0.04795589,0.03570774,0.00009216698,0.01060349],"study_design_scores_gemma":[0.002425828,0.0005509169,0.9802201,0.00006049423,0.0001396094,0.00007156934,0.0001636721,0.0009216623,0.000440775,0.005828485,0.009030207,0.0001466428],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856364,0.004006677,0.00001359277,0.006828086,0.00006865247,0.0005093405,0.000003042595,0.00002489603,0.002909309],"genre_scores_gemma":[0.9969755,0.001176622,0.0006804238,0.0003187123,0.0000144762,0.00008743616,0.0003183773,0.0000112148,0.000417182],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07732746,"threshold_uncertainty_score":0.2706117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0215799095770409,"score_gpt":0.3131147599438619,"score_spread":0.291534850366821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}