{"id":"W2973928903","doi":"10.3390/biom9090501","title":"Immunomodulatory Functions of the Human Cathelicidin LL-37 (aa 13–31)-Derived Peptides are Associated with Predicted α-Helical Propensity and Hydrophobic Index","year":2019,"lang":"en","type":"article","venue":"Biomolecules","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Peptide; Chemokine; Cathelicidin; Cytokine; Chemistry; Amino acid; Peripheral blood mononuclear cell; Biochemistry; In vitro; Molecular biology; Biology; Immunology; Antimicrobial peptides; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001087194,0.0002238185,0.000366189,0.00005991842,0.0003191884,0.00002317544,0.0002056337,0.0002303457,0.00008870255],"category_scores_gemma":[0.00003396586,0.000145743,0.00010399,0.0001592426,0.0009782795,0.00008360037,0.0001848348,0.0002662332,0.00003585033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004003326,"about_ca_system_score_gemma":0.00007293111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006600431,"about_ca_topic_score_gemma":0.0003152077,"domain_scores_codex":[0.9989337,0.0001660867,0.0002461554,0.0003143933,0.00005770901,0.0002819288],"domain_scores_gemma":[0.9991801,0.00004986193,0.000280592,0.0003551241,0.0001130126,0.00002127095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00008796289,0.0001560906,0.1026807,0.00002111459,0.0002509452,0.000001743781,0.0001863791,0.000005625416,0.8957749,0.00006505345,0.0007261017,0.00004343286],"study_design_scores_gemma":[0.001129473,0.0002621749,0.6286358,0.0002040528,0.00007894607,0.00003238915,0.000513363,0.000008801157,0.3686085,0.00002446515,0.0002869877,0.0002150464],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982207,0.0004318685,0.00001630766,0.0001339168,0.0001574714,0.0004354716,0.0001439078,0.00006720176,0.0003931539],"genre_scores_gemma":[0.9968759,0.00001590997,0.00000536254,0.00008874523,0.00001366964,0.00001076904,0.00008281571,0.00002493251,0.002881885],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5271664,"threshold_uncertainty_score":0.5943227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009926756382450459,"score_gpt":0.1952396722113825,"score_spread":0.185312915828932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}