{"id":"W2973928903","doi":"10.3390/biom9090501","title":"Immunomodulatory Functions of the Human Cathelicidin LL-37 (aa 13–31)-Derived Peptides are Associated with Predicted α-Helical Propensity and Hydrophobic Index","year":2019,"lang":"en","type":"article","venue":"Biomolecules","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Peptide; Chemokine; Cathelicidin; Cytokine; Chemistry; Amino acid; Peripheral blood mononuclear cell; Biochemistry; In vitro; Molecular biology; Biology; Immunology; Antimicrobial peptides; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000142442,0.0002790816,0.0002140214,0.0001908603,0.00007279274,0.0002370327,0.00007173538,0.000127241,0.0004365462],"category_scores_gemma":[0.0002170513,0.00008518048,0.0002677022,0.0001492879,0.0001503336,0.0001091577,0.0001191844,0.0001959609,0.0002156753],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001654925,"about_ca_system_score_gemma":0.0001454594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003082249,"about_ca_topic_score_gemma":0.0002759389,"domain_scores_codex":[0.9999231,0.00001553504,0.000008505102,0.0000125329,0.00002011191,0.00002016215],"domain_scores_gemma":[0.999851,0.00003203872,0.0000663309,0.000007534724,0.00001837589,0.00002468904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003446323,0.00002185822,0.004614055,0.00004905007,0.00001160425,0.0001517354,0.00001755362,0.0006364465,0.9905866,0.00004079398,0.00003446312,0.003491278],"study_design_scores_gemma":[0.00003708943,0.000928843,0.07777321,0.00002111787,0.00007589064,0.001665912,0.00005497524,0.01529334,0.90191,0.0002039082,0.002011867,0.00002384498],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973279,0.0006058414,0.001599181,0.00002088645,0.000004145996,0.000009322106,0.0001714129,0.00002367404,0.0002375953],"genre_scores_gemma":[0.9963734,0.00033625,0.002626569,0.00002289886,0.000005635581,0.000008278452,0.000430914,0.000005731211,0.0001904264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004365462,"threshold_uncertainty_score":0.001460373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009926756382450459,"score_gpt":0.1952396722113825,"score_spread":0.185312915828932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}