{"id":"W2974076384","doi":"10.1101/776526","title":"Internalizing Symptoms Associate with the Pace of Epigenetic Aging in Childhood","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; Canadian Institute for Advanced Research; University of British Columbia; McGill University; Douglas Mental Health University Institute","funders":"National Institute of Child Health and Human Development; National Institutes of Health; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Canada First Research Excellence Fund; Jacobs Foundation; Koninklijke Nederlandse Akademie van Wetenschappen; Canadian Institute for Advanced Research","keywords":"Epigenetics; Cohort; Longitudinal study; DNA methylation; Medicine; Early childhood; Psychology; Psychiatry; Developmental psychology; Internal medicine; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003278308,0.0001917091,0.0001793504,0.0004863393,0.0001693793,0.0003907204,0.0001127043,0.0001727006,0.001390804],"category_scores_gemma":[0.0009352307,0.0001766784,0.0002373201,0.0005011839,0.0001749516,0.0001566613,0.0003278271,0.0003293373,0.0001304926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001739956,"about_ca_system_score_gemma":0.0001587105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003750498,"about_ca_topic_score_gemma":0.00537264,"domain_scores_codex":[0.9998715,0.0000251444,0.000009377146,0.00004085349,0.00002358096,0.00002947431],"domain_scores_gemma":[0.9993117,0.00006837275,0.0004199906,0.00006154572,0.00006012959,0.00007815103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00007004655,0.00001635746,0.994348,0.000006971165,0.00003046184,0.00004841837,0.00008763931,0.00003325807,0.003208909,0.00002483886,0.00004474898,0.002080361],"study_design_scores_gemma":[3.422856e-7,0.0000131453,0.9996192,9.914777e-7,0.000004156211,0.0000388609,0.00002740542,0.00001699332,0.0002350619,0.000008934411,0.000034368,5.607675e-7],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992945,0.0001254633,0.0001119815,0.00001769873,0.000002239123,0.000002067851,0.0002433934,0.000004661867,0.0001979439],"genre_scores_gemma":[0.9991567,0.0001171495,0.0001515579,0.000009158459,0.000002901112,0.000003158361,0.0002669815,0.000002812728,0.0002895125],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003750498,"threshold_uncertainty_score":0.007457316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006018775836388345,"score_gpt":0.2114497423121743,"score_spread":0.2054309664757859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}