{"id":"W2974273453","doi":"10.1200/jco.2019.37.15_suppl.e21502","title":"Effective targeted antitumor activity of the antimicrobial agent taurolidine against relapsed/refractory neuroblastoma: Cytotoxicity, target modulation and tumor xenograft studies.","year":2019,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Lethbridge; Alberta Children's Hospital","funders":"","keywords":"Neuroblastoma; Medicine; In vivo; Cancer research; Refractory (planetary science); Bioluminescence imaging; In vitro; Cytotoxicity; Cell culture; Pathology; Oncology; Pharmacology; Biology; Transfection","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003174268,0.0004617403,0.0006973084,0.0002857698,0.0001434465,0.0002212311,0.0003923779,0.0003740863,0.0008946629],"category_scores_gemma":[0.0001195791,0.0001415244,0.0003774381,0.0002532952,0.0002081556,0.0002564137,0.0001378593,0.0006600447,0.0002959969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003565547,"about_ca_system_score_gemma":0.0003327073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001022157,"about_ca_topic_score_gemma":0.002692856,"domain_scores_codex":[0.9998521,0.0000363173,0.00001325839,0.00003190432,0.00003403707,0.00003238774],"domain_scores_gemma":[0.9998851,0.00002024902,0.00002927271,0.00001972769,0.00001810981,0.00002748407],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001092625,0.0009551357,0.000425188,0.0002267786,0.00003228331,0.0001089048,0.00005498542,0.0003983989,0.9889178,0.00007119206,0.0002931718,0.007423538],"study_design_scores_gemma":[0.0004805012,0.03092827,0.01136441,0.00003325763,0.0001299077,0.0008698558,0.00009031863,0.001729455,0.948409,0.00004257433,0.005905313,0.00001721427],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913267,0.005585678,0.0007433694,0.00008874345,0.00006306035,0.00009963441,0.000817538,0.0000523979,0.001222915],"genre_scores_gemma":[0.9914859,0.003879775,0.001451041,0.00004340735,0.00001798112,0.0001006227,0.001279178,0.00001714699,0.001725052],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001022157,"threshold_uncertainty_score":0.002992928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03476014645871837,"score_gpt":0.3618701006542097,"score_spread":0.3271099541954913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}