{"id":"W2974376001","doi":"10.1158/0008-5472.can-18-3029","title":"Chromosomal Instability and mTORC1 Activation through PTEN Loss Contribute to Proteotoxic Stress in Ovarian Carcinoma","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research","keywords":"mTORC1; PTEN; Biology; Cancer research; Chromosome instability; Unfolded protein response; Ovarian cancer; Carcinogenesis; Proteasome; Cancer; Cell biology; PI3K/AKT/mTOR pathway; Signal transduction; Genetics; Chromosome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001439996,0.0001752474,0.0002232665,0.0004538746,0.0002212832,0.0003195915,0.0001240277,0.0001840246,0.0009246098],"category_scores_gemma":[0.0002189098,0.0001211886,0.000168208,0.0003571781,0.0002072502,0.0001311228,0.0002863977,0.000331989,0.0001583178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003660489,"about_ca_system_score_gemma":0.000235996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007734015,"about_ca_topic_score_gemma":0.0008012024,"domain_scores_codex":[0.9999176,0.00001127267,0.000009874583,0.00001216085,0.00002685596,0.00002225724],"domain_scores_gemma":[0.9998986,0.00001347447,0.0000415201,0.000009624309,0.00001131638,0.00002550296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009162586,0.0001065286,0.02082689,0.00009206258,0.00003695472,0.000900128,0.00005511302,0.0004834553,0.9705812,0.00016614,0.0002045716,0.005630706],"study_design_scores_gemma":[0.0001130443,0.001713056,0.321792,0.00001914019,0.0001194803,0.007442911,0.0002919826,0.004999542,0.6581992,0.0004186278,0.004870885,0.00002006031],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998688,0.0005205342,0.0002895462,0.00005399723,0.000004550534,0.00001132196,0.00009907893,0.00002171802,0.0003112656],"genre_scores_gemma":[0.9993736,0.0002036328,0.0000975778,0.00001416364,0.000002659879,0.000008928503,0.00009543348,0.000002457416,0.0002015873],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009246098,"threshold_uncertainty_score":0.003093123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02459114106865675,"score_gpt":0.3424777985314327,"score_spread":0.3178866574627759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}