{"id":"W2974470008","doi":"10.1038/s41598-019-49840-4","title":"Application of a chemical probe to detect neutrophil elastase activation during inflammatory bowel disease","year":2019,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kingston General Hospital; Queen's University","funders":"National Institute of Dental and Craniofacial Research; National Institute of Neurological Disorders and Stroke; National Health and Medical Research Council; Medical Research Council; National Institutes of Health; Australian Research Council; Crohn's and Colitis Canada; Department of Education and Training; University of Melbourne; Monash University; Deutsche Forschungsgemeinschaft; National Institute of Diabetes and Digestive and Kidney Diseases; U.S. Department of Defense","keywords":"Inflammatory bowel disease; Elastase; Neutrophil elastase; Inflammatory Bowel Diseases; Immunology; Inflammation; Medicine; Chemistry; Disease; Biochemistry; Pathology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003159859,0.0003837323,0.0001640147,0.0003638288,0.0001606967,0.0002194983,0.0001889109,0.0007199164,0.001055649],"category_scores_gemma":[0.0002437998,0.0001791062,0.0001931631,0.0002303331,0.0002556601,0.0002197794,0.0002135316,0.0005722193,0.0002570653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00022806,"about_ca_system_score_gemma":0.0001199989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002384303,"about_ca_topic_score_gemma":0.0003720494,"domain_scores_codex":[0.9997535,0.00007129709,0.00001353197,0.00005191393,0.0000558077,0.0000538835],"domain_scores_gemma":[0.9998426,0.00004895022,0.00004272097,0.00001487262,0.00001986567,0.00003089585],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002937137,0.0000103482,0.0000770706,0.00001693391,0.000001623249,0.00001838886,0.000006731638,0.0000151084,0.999272,0.00002265251,0.000009907265,0.0005197056],"study_design_scores_gemma":[0.000008015169,0.000490638,0.002771974,0.000005386634,0.000008746689,0.0002284767,0.00001995138,0.000426158,0.9951462,0.0000283054,0.0008620418,0.000003975371],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9621698,0.004259949,0.02986592,0.0002603386,0.00007219676,0.0001014133,0.0001877939,0.000166453,0.002916272],"genre_scores_gemma":[0.9656014,0.001592959,0.02970248,0.0002475529,0.00003748517,0.0001276441,0.0002855337,0.00002066543,0.002384196],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001055649,"threshold_uncertainty_score":0.003531516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005417054548657435,"score_gpt":0.2102525742757029,"score_spread":0.2048355197270455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}